C1389

Carbenicillin disodium salt

89.0-100.5% anhydrous basis

• 동의어(들): Carbenicillin, Disodium carbenicillin, α-Carboxybenzylpenicillin disodium salt
• 실험식(Hill 표기법): C₁₇H₁₆N₂Na₂O₆S
• CAS Number: 4800-94-6
• Molecular Weight: 422.36
• Beilstein: 5722128
• EC Number: 225-360-8
• MDL number: MFCD00077683
• UNSPSC 코드: 51282413
• PubChem Substance ID: 24892409
• NACRES: NA.76

속성

• 생물학적 소스: synthetic (chemical)
• Quality Level: 200
• 분석: 89.0-100.5% anhydrous basis
• 양식: powder
• 색상: white to off-white
• solubility: H₂O: 50 mg/mL
• 항생제 활성 스펙트럼: Gram-negative bacteria; Gram-positive bacteria
• 동작 모드: cell wall synthesis | interferes
• 저장 온도: 2-8°C
• SMILES string: [Na+].[Na+].CC1(C)S[C@@H]2[C@H](NC(=O)C(C([O-])=O)c3ccccc3)C(=O)N2[C@H]1C([O-])=O
• InChI: 1S/C17H18N2O6S.2Na/c1-17(2)11(16(24)25)19-13(21)10(14(19)26-17)18-12(20)9(15(22)23)8-6-4-3-5-7-8;;/h3-7,9-11,14H,1-2H3,(H,18,20)(H,22,23)(H,24,25);;/q;2*+1/p-2/t9?,10-,11+,14-;;/m1../s1
• InChI key: RTYJTGSCYUUYAL-YCAHSCEMSA-L

설명

일반 설명

Carbenicillin is a semi-synthetic, broad-spectrum carboxypenicillin antibiotic with bactericidal and beta-lactamase resistant activity. It is a broad-spectrum antibiotic, meaning that it is effective against a wide range of bacteria, including both Gram-positive and Gram-negative bacteria. Carbenicillin is particularly useful against Pseudomonas aeruginosa, a Gram-negative bacterium that is often resistant to other antibiotics.

Carbenicillin is commonly used in cell biology applications to prevent the growth of bacterial contaminants. It is also used in microbiology to select for bacteria that have been transformed with a vector harboring the gene encoding beta-lactamase, which makes them resistant to carbenicillin.

애플리케이션

Carbenicillin disodium salt has been used:

• in the preparation of Luria-Bertani (LB) agar plates and media
• as a selective agent in the culture media to prevent the growth of bacterial contaminants
• in a study focused on the development of monoclonal antibodies

생화학적/생리학적 작용

Mode of Action: Carboxypenicillin antibiotic that inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking) by inactivating transpeptidases on the inner surface of the bacterial cell membrane.


Antimicrobial spectrum: Active against Gram-positive and Gram-negative bacteria

Carbenicillin acylates the penicillin-sensitive transpeptidase C-terminal domain by opening the lactam ring. This inactivation prevents the cross-linkage of peptidoglycan strands, thereby inhibiting the third and last stage of bacterial cell wall synthesis. This leads to incomplete bacterial cell wall synthesis and eventually causes cell lysis.

특징 및 장점

• Broad-spectrum antibiotic with bactericidal and beta-lactamase resistant activity
• Effective against a wide range of bacteria, including Pseudomonas aeruginosa
• Commonly used in Cell Biology and Biochemical applications
• Offers greater stablility than ampicillin

저장 및 안정성

Tightly closed. Dry. Keep locked up or in an area accessible only to qualified or authorized

분석 메모

Stable at 37 °C for 3 days

기타 정보

For additional information on our range of Biochemicals, please complete this form.

Keep container tightly closed in a dry and well-ventilated place.

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H317,H334
• 예방조치 성명서: P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313
• Hazard Classifications: Resp. Sens. 1 - Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves