추천 제품
생물학적 소스
guinea pig
Quality Level
항체 형태
serum
항체 생산 유형
primary antibodies
클론
polyclonal
종 반응성
rat, mouse
기술
immunocytochemistry: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable
배송 상태
wet ice
타겟 번역 후 변형
unmodified
유전자 정보
mouse ... Rbfox3(52897)
rat ... Rbfox3(287847)
일반 설명
ABN90 is a Guinea Pig polyclonal version of the Anti-NeuN, clone A60 (MAB377), a highly characterized and cited mouse monoclonal antibody that specifically recognizes the DNA-binding, neuron-specific protein NeuN, which is present in most CNS and PNS neuronal cell types of all vertebrates tested. NeuN protein distributions are apparently restricted to neuronal nuclei, perikarya and some proximal neuronal processes in both fetal and adult brain although, some neurons fail to be recognized by NeuN at all ages: INL retinal cells, Cajal-Retzius cells, Purkinje cells, inferior olivary and dentate nucleus neurons, and sympathetic ganglion cells are some examples. Immunohistochemically detectable NeuN protein first appears at developmental timepoints that correspond with the withdrawal of the neuron from the cell cycle and/or with the initiation of terminal differentiation of the neuron. Immunoreactivity appears around E9.5 in the mouse neural tube and is extensive throughout the developing nervous system by E12.5. Strong nuclear staining suggests a nuclear regulatory protein function; however, no evidence currently exists as to whether the NeuN protein antigen has a function in the distal cytoplasm or whether it is merely synthesized there before being transported back into the nucleus. No difference between protein isolated from purified nuclei and whole brain extract on immunoblots has been found.
애플리케이션
- Immunohistochemistry (Paraffin) Analysis: A 1:5,000 dilution from a representative lot detected NeuN in mouse cerebral cortex and hippocampus brain tissue sections.
- Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected NeuN in rat E18 cortical cells.
- Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user.
This guinea pig polyclonal Anti-NeuN, Cat. No. ABN90 is tested for use in Western Blotting, Immunocytochemistry and Immunohistochemistry (Paraffin), for the detection of NeuN.
품질
Evaluated by Western Blotting in Mouse E16 brain tissue lysate. Western Blotting Analysis: A 1:2,000 Dilution of this antibody detected NeuN in Mouse E16 brain tissue lysate.
표적 설명
~48 kDa observed
물리적 형태
Guinea pig polyclonal serum containing 0.05% sodium azide.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
시험 성적서(COA)
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