추천 제품
생물학적 소스
chicken
Quality Level
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
정제법
affinity chromatography
종 반응성
human, mouse, rat
종 반응성(상동성에 의해 예측)
opossum (based on 100% sequence homology), horse (based on 100% sequence homology), canine (based on 100% sequence homology), bovine (based on 100% sequence homology), pig (based on 100% sequence homology)
기술
immunohistochemistry: suitable
western blot: suitable
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
타겟 번역 후 변형
unmodified
유전자 정보
mouse ... Tbr1(21375)
일반 설명
Tbr1 gene is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Tbr1, a putative transcription factor known to be expressed in post-mitotic neurons, has been found highly expressed in glutamatergic early-born cortical neurons. A similar protein has been disrupted in mice and shown to be critical for early cortical development, and causes loss of projection neurons in the olfactory bulbs and olfactory cortex. The C-terminal region the Tbr1 derived protein was found to be necessary and sufficient for association with the guanylate kinase domain of calcium/calmodulin-dependent serine protein kinase.
특이성
This antibody recognizes Tbr1.
면역원
Epitope: Internal
KLH-conjugated linear peptide corresponding to mouse Tbr1.
애플리케이션
Anti-Tbr1 Antibody is an antibody against Tbr1 for use in WB, IH.
Immunohistochemistry Analysis: 1:100 dilution from a previous lot detected Tbr1 in mouse frontal cortex tissue.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Developmental Neuroscience
Developmental Neuroscience
품질
Evaluated by Western Blot in human fetal brain tissue lysate.
Western Blot Analysis: 0.025 µg/ml of this antibody detected Tbr1 on 10 µg of human fetal brain tissue lysate.
Western Blot Analysis: 0.025 µg/ml of this antibody detected Tbr1 on 10 µg of human fetal brain tissue lysate.
표적 설명
~ 68 kDa is observed; however, UniProtKB/Swiss-Prot entry Q64336 (TBR1_MOUSE) lists a mass of 73.941 kDa
물리적 형태
Affinity purified
Purified chicken polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
저장 및 안정성
Stable for 1 year at 2-8°C from date of receipt.
분석 메모
Control
Human fetal brain tissue lysate
Human fetal brain tissue lysate
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Tadashi Nomura et al.
Cell reports, 31(5), 107592-107592 (2020-05-07)
The six-layered neocortex is a shared characteristic of all mammals, but not of non-mammalian species, and its formation requires an inside-out pattern of neuronal migration. The extant reptilian dorsal cortex is thought to represent an ancestral form of the neocortex
Anna Gorelik et al.
Nature communications, 8, 15096-15096 (2017-05-04)
In recent years the notion that malfunctioning of the immune system may result in developmental brain diseases has emerged. However, the role of immune molecules in the developing brain has not been well explored. The complement pathway converges to cleave
Livio Oboti et al.
eNeuro, 5(3) (2018-06-19)
Interconnections between the olfactory bulb and the amygdala are a major pathway for triggering strong behavioral responses to a variety of odorants. However, while this broad mapping has been established, the patterns of amygdala feedback connectivity and the influence on
Naoki Nakagawa et al.
Genes & development, 31(16), 1679-1692 (2017-09-17)
Adenomatous polyposis coli (APC) regulates the activity of β-catenin, an integral component of Wnt signaling. However, the selective role of the APC-β-catenin pathway in cerebral cortical development is unknown. Here we genetically dissected the relative contributions of APC-regulated β-catenin signaling
Lei Wang et al.
Nature neuroscience, 19(7), 888-896 (2016-05-24)
The unique mental abilities of humans are rooted in the immensely expanded and folded neocortex, which reflects the expansion of neural progenitors, especially basal progenitors including basal radial glia (bRGs) and intermediate progenitor cells (IPCs). We found that constitutively active
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