569406

Stearoyl-CoA Desaturase 1 Inhibitor, MF-438

Stearoyl-CoA Desaturase 1 Inhibitor, MF-438, CAS 921605-87-0, is a cell-permeable inhibitor of Stearoyl-CoA Desaturase 1 (SCD1; IC50 of 2.3 nM).

• 동의어(들): Stearoyl-CoA Desaturase 1 Inhibitor, MF-438, 2-methyl-5-(6-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)pyridazin-3-yl)-1,3,4-thiadiazole
• 실험식(Hill 표기법): C₁₉H₁₈F₃N₅OS
• Molecular Weight: 421.44
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥99% (HPLC)
• 양식: powder
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• 색상: off-white
• solubility: DMSO: 10 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C

설명

일반 설명

A cell-permeable, thiadiazole-pyridazine compound that acts as an inhibitor of Stearoyl-CoA Desaturase 1 (SCD1) with an IC₅₀ of 2.3 nM. In vivo, it exhibits an ED₅₀ of 1-3 mg/kg, p.o., in mouse liver PD assays.

경고

Toxicity: Standard Handling (A)

기타 정보

Leger, S., et al. 2010. Bioorg Med Chem Lett.2, 499.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable