3541

Glutathione, Reduced, Free Acid

>98% (titration), solid, endogenous antioxidant, Calbiochem^®

• 동의어(들): Glutathione, Reduced, Free Acid, γ-Glu-Cys-Gly, GSH
• 실험식(Hill 표기법): C₁₀H₁₇N₃O₆S
• CAS Number: 70-18-8
• Molecular Weight: 307.32
• MDL number: MFCD00065939
• UNSPSC 코드: 12352209
• NACRES: NA.25

속성

• 제품명: Glutathione, Reduced, Free Acid, Glutathione, Reduced, Free Acid, CAS 70-18-8, is a tripeptide that serves as an endogenous antioxidant and provides protection against auto-oxidation.
• Quality Level: 200
• 설명: RTECS - MC0556000; Merck USA index - 14, 4475
• 분석: >98% (titration)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic)
• 색상: white
• solubility: water: 1 mg/mL; DMF: 10 mg/mL; ethanol: 5 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• SMILES string: SCC(NC(=O)CCC([N+H3])C(=O)[O-])C(=O)NCC(=O)O
• InChI: 1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)
• InChI key: RWSXRVCMGQZWBV-UHFFFAOYSA-N

설명

일반 설명

Glutathione is a tripeptide composed of cysteine, glycine, and glutamic acid. In cells glutathione either exists as reduced (GSH) and oxidized (GSSG). The ratio of glutathione reduced (GSH) to glutathione oxidized (GSSG) determines the cell’s redox status. Healthy resting cells have a GSH/GSSG ratio >100. In cells under oxidative stress, the GSH/GSSG ratio drops to between 1 and 10. Glutathione has also been identified as the thiol buffer that keeps sulfohydryl groups in the reduced form of many proteins. It is produced solely in the cytochrome P450 system and actively pumped to mitochondria. GSH depletion can lead to Neurodegenerative disorders, Pulmonary disease, Immune diseases, Cardiovascular diseases, Chronic age-related diseases, Liver disease, Cystic fibrosis and Aging process itself.

애플리케이션

Glutathione, Reduced, Free Acid has been used to elute the GST-OTUD6A proteins after purification using Glutathione Sepharose.

생화학적/생리학적 작용

Cell permeable: no

Product does not compete with ATP.

Reversible: no

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable