08-115

Rat Collagen Type I

from rat tail, liquid, 2-5 mg/mL, suitable for cell culture, used for 3D gel formation

• 동의어(들): Rat tail collagen, Rat tail collagen type I
• UNSPSC 코드: 12352202
• eCl@ss: 32160405
• NACRES: NA.75

속성

• 제품명: Collagen Type I, rat tail,
• 생물학적 소스: rat
• Quality Level: 100
• 양식: liquid
• 제조업체/상표: Upstate^®
• 기술: cell culture | mammalian: suitable
• 입력: sample type hematopoietic stem cell(s); sample type mesenchymal stem cell(s); sample type induced pluripotent stem cell(s); sample type epithelial cells; sample type pancreatic stem cell(s); sample type neural stem cell(s); sample type: mouse embryonic stem cell(s)
• NCBI 수납 번호: NM_000088.3
• UniProt 수납 번호: P02452
• 배송 상태: wet ice
• 저장 온도: 2-8°C
• 유전자 정보: rat ... COL1A1(29393)

설명

일반 설명

In humans, type I collagen is the most abundant and broadly expressed collagen. This heterotrimer contains two alpha 1 (I) chains and one alpha 2 (I) chain. Collagen type I α 1 (COL1A1), a major component of collagen type I, codes for pro-α 1 chains of type I collagen. It has repeating Gly-Xaa-Yaa tri-peptides motifs. The collagen alpha-1(I) chain protein is a member of the collagen complex superfamily. COL1A1 has a von Willebrand factor type C (vWFC) domain, a collagen triple-helix repeat, and a fibrillar collagen C-terminal domain (COLF).

애플리케이션

Collagen Type I, rat tail has been used:

• for collagen 3D proliferation assays
• for atelocollagen proliferation assays
• in a comparative study to make microcapsules for templating on mesoporous cores of pure vaterite calcium carbonate (CaCO3) crystals to evaluate the structure-property relationship
• in coverslip coating to grow the human cerebral microvascular endothelial cell line (hCMEC/D3) for creating a cell coculture and chronic subdural hematoma (CSDH) patient hematoma sample induced injury model

생화학적/생리학적 작용

Collagen type I α 1 (COL1A1) plays a key role in chemoresistance and may act as a therapeutic target. It is involved in carboplatin-resistant ovarian cancer (OV). COL1A1 serves as an oncogene in the development of colorectal cancer (CRC). Dominant inherited COL1A1 gene mutations result in connective tissue disorders such as osteogenesis imperfecta (OI).

품질

Routinely evaluated by testing for uniform gelation and for attachment of and spreading of PC-12 rat cells

물리적 형태

0.02N acetic acid, pH 3.67

저장 및 안정성

1 year at 4°C

법적 정보

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable