추천 제품
분석
>99% (TLC)
양식
powder
포장
pkg of 1 × 1 mg (700151P-1mg)
제조업체/상표
Avanti Research™ - A Croda Brand 700151P
배송 상태
dry ice
저장 온도
−20°C
일반 설명
Cholestenoic acid levels in plasma ranges between 100-300 nM and is synthesized in brain. Cholestenoic acid is generated by the side chain oxidation of 27-hydroxy-cholesterol and is an intermediate in the bile synthesis pathway.
Cholestenoic acid-d5 is an endogenous cholesterol metabolite. It is produced in extrahepatic organs.
생화학적/생리학적 작용
Cholestenoic acid is a carboxylic acid γ-secretase modulator. Cholestenoic acid also serves as a ligand for liver X receptor. Cholestenoic acid -d5 regulates amyloid β peptides (Aβ) levels. It reduces Aβ42 levels and enhances Aβ38 levels. In retina, it is the major byproduct of cholesterol elimination. 27-hydroxycholesterol and cholestenoic acid are part of reverse cholesterol transport in macrophages and their transport impairment is implicated in premature atherosclerosis.
Cholestenoic acid-d5 functions as a potent steroid γ-secretase modulator (GSM).
포장
5 mL Amber Glass Screw Cap Vial (700151P-1mg)
법적 정보
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Cholestenoic acid, an endogenous cholesterol metabolite, is a potent gamma-secretase modulator
Jung JI, et al.
Mol. Neurodegener., 10(1), 29-29 (2015)
Cholestenoic acid is an important elimination product of cholesterol in the retina: comparison of retinal cholesterol metabolism with that in the brain
Mast N, et al.
Investigative Ophthalmology & Visual Science, 52(1), 594-603 (2011)
Diseases of the Liver in Children (2014)
Cholestenoic acid is a naturally occurring ligand for liver X receptor alpha
Song C and Liao S
Endocrinology, 141(11), 4180-4184 (2000)
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