700022P

7-keto-27-hydroxycholesterol

Avanti Research^™ - A Croda Brand

• 동의어(들): 3β,27-dihydroxy-5-cholesten-7-one
• 실험식(Hill 표기법): C₂₇H₄₄O₃
• CAS Number: 240129-30-0
• Molecular Weight: 416.64
• MDL number: MFCD00057815
• UNSPSC 코드: 12352211
• NACRES: NA.25

속성

• 분석: >99% (TLC)
• 양식: powder
• 포장: pkg of 1 × 1 mg (700022P-1mg)
• 제조업체/상표: Avanti Research^™ - A Croda Brand
• 배송 상태: dry ice
• 저장 온도: −20°C

설명

일반 설명

7-keto-27-hydroxycholesterol interconversion to 7β,(25R)26-dihydroxycholesterol (7β,26-diHC) is catalyzed by hydroxysteroid 11-β dehydrogenase. It is also formed by the oxidation of 7-oxocholesterol (7-OC) in the presence of enzyme by sterol 26-hydroxylase (CYP27A1).

애플리케이션

7-keto-27-hydroxycholesterol has been used as an oxysterol compound to study its interaction with smoothened (SMO) protein, as a substrate to 11β-hydroxysteroid dehydrogenases (11β-HSDs) for kinetic measurement studies,

생화학적/생리학적 작용

7-keto-27-hydroxycholesterol (7-OC) acts as an agonist for the smoothened (SMO) protein of Hedgehog (Hh) signalling pathway, which is vital for proper cell differentiation in embryonic tissue. It elicits strong affinity to SMO compared to 7β,(25R)26-dihydroxycholesterol (7β,26-diHC). 7-OC is reduced to 7β,(25R)26-dihydroxycholesterol (7β,26-diHC) by reactive oxygen species (ROS).

포장

5 mL Amber Glass Screw Cap Vial (700022P-1mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

안전성 정보

• Storage Class Code: 11 - Combustible Solids