C4706

Tris(2-carboxyethyl)phosphine hydrochloride

powder

• 동의어(들): TCEP
• 실험식(Hill 표기법): C₉H₁₅O₆P · HCl
• CAS Number: 51805-45-9
• Molecular Weight: 286.65
• Beilstein: 3724376
• MDL number: MFCD00145469
• UNSPSC 코드: 12352128
• PubChem Substance ID: 57654018
• NACRES: NA.22

속성

• 설명: Protect from moisture
• Quality Level: 300
• 양식: powder
• 반응 적합성: reagent type: reductant
• 색상: white
• mp: 175-177 °C
• solubility: H₂O: 50 mg/mL
• density: 1.041 g/cm³ at 25 °C
• 저장 온도: 2-8°C
• SMILES string: Cl[H].OC(=O)CCP(CCC(O)=O)CCC(O)=O
• InChI: 1S/C9H15O6P.ClH/c10-7(11)1-4-16(5-2-8(12)13)6-3-9(14)15;/h1-6H2,(H,10,11)(H,12,13)(H,14,15);1H
• InChI key: PBVAJRFEEOIAGW-UHFFFAOYSA-N

설명

일반 설명

Tris(2-carboxyethyl)phosphine hydrochloride (TCEP.HCl) is a non-volatile solid. It is a strong reducing agent.1 It can be synthesized by the acid hydrolysis of tris(2-cyanoethyl)phosphine in refluxing aqueous HCl.1 It has various biological applications such as in vitro and in vivo reduction of disulfide bonds in various peptides and proteins. TCEP is a useful chelating agent for various heavy metal ions as Zn(II), Cd(II), Pb(II), and Ni(II).

애플리케이션

Tris(2-carboxyethyl)phosphine hydrochloride (TCEP. HCl) can be used:

• As a reducing agent for the reduction of sulfoxides, sulfonyl chlorides, N-oxides, and azides. It can also be used in azide-alkyne cycloaddition reaction in the presence of a copper catalyst.
• To reduce disulfide bonds in various proteins.
• As a reagent for the selective reduction of disulfides in water.
• To remove ruthenium-derived metathesis catalysts via aqueous washing of a crude reaction mixture when it is basified.
• As a reducing agent for the reduction of various alkyl disulfides such as trans-4,5-dihydroxy-1,2-dithiane.

Water soluble reagent, used for selective reduction of disulfides. More stable than DTT and useful in mass spectrometry applications.

주의사항

Storage conditions:protect from moisture.

안전성 정보

• 픽토그램: GHS05
• 신호어: Danger
• 유해 및 위험 성명서: H314
• 예방조치 성명서: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Hazard Classifications: Eye Dam. 1 - Skin Corr. 1B
• Storage Class Code: 8A - Combustible corrosive hazardous materials
• WGK: WGK 1
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges