936618

(S,R,S)-AHPC-CO-PEG4-C2-amine HCl

≥95%

• 동의어(들): (2S,4R)-1-((S)-1-amino-17-(tert-butyl)-15-oxo-3,6,9,12-tetraoxa-16-azaoctadecan-18-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride, (2S,4R)-1-[(2S)-2-(1-amino-3,6,9,12-tetraoxapentadecan-15-amido)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide hydrochloride
• 실험식(Hill 표기법): C₃₃H₅₁N₅O₈S · xHCl
• CAS Number: 2376139-48-7
• Molecular Weight: 677.85 (free base basis)
• MDL number: MFCD33020916
• UNSPSC 코드: 12352106
• NACRES: NA.22

속성

• Quality Level: 100
• 분석: ≥95%
• 양식: crystals (or crystals with chunks)
• 색상: White to Light Yellow
• 저장 온도: 2-8°C
• SMILES string: C([C@@H](NC(CCOCCOCCOCCOCCN)=O)[C@](C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1.Cl
• InChI: 1S/C33H51N5O8S.ClH/c1-23-29(47-22-36-23)25-7-5-24(6-8-25)20-35-31(41)27-19-26(39)21-38(27)32(42)30(33(2,3)4)37-28(40)9-11-43-13-15-45-17-18-46-16-14-44-12-10-34;/h5-8,22,26-27,30,39H,9-21,34H2,1-4H3,(H,35,41)(H,37,40);1H/t26-,27+,30-;/m1./s1
• InChI key: XKGVWUPEGSRRJY-ABLBDAGXSA-N

설명

애플리케이션

(S,R,S)-AHPC-CO-PEG4-C2-amine HCl is a functionalized functionalized von Hippel-Lindau (VHL) ligand. It contains a terminal amine for conjugation with carboxylic acid linkers. A basic building block for development of a protein degrader library.


Technology Spotlight:

Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

기타 정보

Targeted Protein Degradation by Small Molecules
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable