936596
1H-Isoindole-1,3(2H)-dione, 4-[(4-aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride
≥95%
동의어(들):
4-((4-aminobutyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C17H20N4O4 · xHCl
CAS Number:
Molecular Weight:
344.37 (free base basis)
MDL number:
UNSPSC 코드:
12161600
NACRES:
NA.22
추천 제품
![[4,4′-Bis(1,1-dimethylethyl)-2,2′-bipyridine] nickel (II) dichloride](/deepweb/assets/sigmaaldrich/product/structures/471/091/6faa29b1-bf8a-4d87-90b2-4cc55e082620/640/6faa29b1-bf8a-4d87-90b2-4cc55e082620.png)
![[4,4′-Dimethyl-2,2′-bipyridine]nickel(II) dichloride hydrate ≥95%](/deepweb/assets/sigmaaldrich/product/structures/714/807/6f838a65-cb7b-400f-bdb3-3e207bb2ddc4/640/6f838a65-cb7b-400f-bdb3-3e207bb2ddc4.png)
![L-Prolinamide, N-[3-[2-(2-aminoethoxy)ethoxy]-1-oxopropyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- HCl ≥95.0%](/deepweb/assets/sigmaaldrich/product/structures/412/427/7c030a54-6d2b-4b19-8e4a-a821d42b1d1f/640/7c030a54-6d2b-4b19-8e4a-a821d42b1d1f.png)
Quality Level
분석
≥95%
양식
powder or crystals
색상
light yellow to yellow
저장 온도
2-8°C
SMILES string
Cl.O=C1NC(=O)C(N2C(=O)C=3C=CC=C(NCCCCN)C3C2=O)CC1
InChI
1S/C17H20N4O4.ClH/c18-8-1-2-9-19-11-5-3-4-10-14(11)17(25)21(16(10)24)12-6-7-13(22)20-15(12)23;/h3-5,12,19H,1-2,6-9,18H2,(H,20,22,23);1H
InChI key
RPZIYPJCEKKGPO-UHFFFAOYSA-N
애플리케이션
A functionalized cereblon ligand for development of Thalidomide based PROTACs. Allows rapid conjugation with carboxyl linkers due to presence of amine group via peptide coupling reactions. A basic building block for making protein degrader library.
Technology Spotlight:
Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks
Technology Spotlight:
Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks
기타 정보
Targeted Protein Degradation by Small Molecules
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs
법적 정보
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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