936383

Mc-Val-Cit-PAB

≥95%

• 동의어(들): 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino]-1-oxo-5-ureidopentan-2-yl)amino]-3-methyl-1-oxobutan-2-yl)hexanamide, N-[(1S)-1-[[(1S)-4-(carbamoylamino)-1-[[4-(hydroxymethyl)phenyl]carbamoyl]butyl]carbamoyl]-2-methylpropyl]-6-(2,5-dioxopyrrol-1-yl)hexanamide, N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide (ACI), L-Ornithinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]- (9CI, ACI)
• 실험식(Hill 표기법): C₂₈H₄₀N₆O₇
• Molecular Weight: 572.65
• MDL number: MFCD26142966
• UNSPSC 코드: 12352209

속성

• Quality Level: 100
• 분석: ≥95%
• 양식: powder or crystals
• 색상: white to yellow
• 저장 온도: −20°C
• SMILES string: [C@@H](NC([C@@H](NC(CCCCCN1C(=O)C=CC1=O)=O)[C@H](C)C)=O)(C(NC2=CC=C(CO)C=C2)=O)CCCNC(N)=O
• InChI: 1S/C28H40N6O7/c1-18(2)25(33-22(36)8-4-3-5-16-34-23(37)13-14-24(34)38)27(40)32-21(7-6-15-30-28(29)41)26(39)31-20-11-9-19(17-35)10-12-20/h9-14,18,21,25,35H,3-8,15-17H2,1-2H3,(H,31,39)(H,32,40)(H,33,36)(H3,29,30,41)/t21-,25-/m0/s1
• InChI key: AMKBTTRWLGVRER-OFVILXPXSA-N

설명

애플리케이션

This is a bifunctional cathepsin cleavable linker used in the construction of antibody drug conjugates (ADC).

특징 및 장점

The maleimide functionality can be used for bioconjugation to thiols in monoclonal antibodies while the benzyl alcohol can be used for construction of carbamate linkages with amine containing payloads.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable