CH2900010

Calcium Folinate Hydrate amorphous / Leucovorin Calcium amorphous

USP, Ph. Eur.

• Synonyma: Folinic acid calcium salt, Calcii Folinas, Calcium Folinate, Leucovorin Calcium, Calcium folinate
• Empirický vzorec (Hillův zápis): C₂₀H₂₁CaN₇O₇
• CAS Number: 1492-18-8
• Molekulová hmotnost: 511.50
• MDL number: MFCD00006704
• UNSPSC Code: 41116107

Vlastnosti

• biological source: synthetic
• Quality Level: 600
• grade: GMO free; GMP; Halal; Kosher
• agency: Ph. Eur.; USP
• form: powder
• application(s): liquid formulation; pharmaceutical
• storage temp.: 2-8°C
• SMILES string: [Ca+2].[nH]1c2c([c](nc1N)=O)N(C(CN2)CNc3ccc(cc3)C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-])C=O
• InChI: 1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/q;+2/p-2/t12?,13-;/m0./s1
• InChI key: KVUAALJSMIVURS-ZEDZUCNESA-L

Popis

General description

We provide industry-leading production know-how and comprehensive regulatory support for high-quality APIs, backed by nearly 200 years of experience. From a complete portfolio of innovative folates to custom synthesis, our customized and scalable solutions meet your specific production needs. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Calcium Folinate Hydrate amorphous has three main clinical applications:
1) First line treatment for colorectal cancer: In combination with the anticancer drug 5-fluorouracil (5-FU), Irinotecan, Cisplatin or Oxaliplatin, and its derivatives. Calcium Folinate is a modulator of 5-FU and enhances its efficacy in cancer chemotherapy.
2) Treatment of certain neoplastic diseases, severe psoriasis, and adult rheumatoid arthritis as a rescue therapy to reduce the toxic side effects of intermediate or high doses of methotrexate.
3) Treatment of anemia caused by folate deficiency.

Packaging

Customized packaging possible

Legal Information

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Bezpečnostní informace

• Skladovací třída: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable