1437202

Méthylpyrrolidone

United States Pharmacopeia (USP) Reference Standard

• Synonyme(s) : 1-Méthyl-2-pyrrolidinone, 1-méthyl-2-pyrrolidone, N-méthyl-2-pyrrolidone, M-PYROL, NMP
• Formule empirique (notation de Hill) : C₅H₉NO
• Numéro CAS: 872-50-4
• Poids moléculaire : 99.13
• Beilstein: 106420
• Numéro MDL: MFCD00003193
• Code UNSPSC : 41116107
• ID de substance PubChem : 329750275
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: pharmaceutical primary standard
• Densité de vapeur: 3.4 (vs air)
• Pression de vapeur: 0.29 mmHg ( 20 °C); 0.99 mmHg ( 40 °C)
• Forme: liquid
• Température d'inflammation spontanée: 518 °F
• Limite d'explosivité: 9.5 %
• Fabricant/nom de marque: USP
• Indice de réfraction: n20/D 1.47 (lit.)
• pb: 202 °C (lit.); 81-82 °C/10 mmHg (lit.)
• Pf: −24 °C (lit.)
• Densité: 1.028 g/mL at 25 °C (lit.)
• Application(s): pharmaceutical (small molecule)
• Format: neat
• Chaîne SMILES: CN1CCCC1=O
• InChI: 1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3
• Clé InChI: SECXISVLQFMRJM-UHFFFAOYSA-N

Description

Description générale

Methylpyrrolidone is a highly polar solvent used in biologics formulations, particularly for drugs that require solubilization of hydrophobic compounds. It facilitates the delivery and stability of poorly soluble biologics by enhancing their dissolution properties. NMP is widely used in drug delivery systems, contributing to more efficient therapeutic delivery.

The United States Pharmacopeia (USP) provides quality standards for biologics to ensure their safety, efficacy, and quality throughout the manufacturing process. These standards assist manufacturers in adhering to regulatory requirements and help safeguard public health by reducing risks associated with biologics.

This compound is listed in the SVHC (Substances of very high concern) candidate list of ECHA (European Chemicals Agency)

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Methylpyrrolidone USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

Remarque sur l'analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Autres remarques

This compound is listed in the SVHC (Substances of very high concern) candidate list of ECHA (European Chemicals Agency)This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

This product is part of USP Biologics Program.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pha

Sales restrictions may apply.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H315,H319,H335,H360D
• Conseils de prudence: P202 - P261 - P264 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Classification des risques: Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): 195.8 °F - Pensky-Martens closed cup
• Point d'éclair (°C): 91 °C - Pensky-Martens closed cup