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1005706

USP

Acide acétique glacial

United States Pharmacopeia (USP) Reference Standard

Synonyme(s) :

Acide acétique, Acide acétique glacial

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About This Item

Formule linéaire :
CH3CO2H
Numéro CAS:
64-19-7
Poids moléculaire :
60.05
Beilstein:
506007
Numéro MDL:
MFCD00036152
Code UNSPSC :
41116107
ID de substance PubChem :
329748133
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Densité de vapeur

2.07 (vs air)

Famille d'API

glacial acetic acid

Forme

liquid

Température d'inflammation spontanée

800 °F

Limite d'explosivité

16 %, 92 °F
4 %, 59 °F

Fabricant/nom de marque

USP

Technique(s)

gas chromatography (GC): suitable

Indice de réfraction

n20/D 1.371 (lit.)

pb

117-118 °C (lit.)

Pf

16.2 °C (lit.)

Densité

1.04 g/mL at 25 °C (lit.)

Application(s)

pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

[F2C(F2C)13F3C]C(O)=O

InChI

1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)

Clé InChI

QTBSBXVTEAMEQO-UHFFFAOYSA-N

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Catégories apparentées

Description générale

Glacial acetic acid is a commonly used solvent and pH modifier in peptide synthesis and purification. It may be present as a residual process reagent. The USP standard is used to quantify acetic acid levels in peptide APIs and assess formulation stability.

The USP biologics peptides category encompasses a diverse range of therapeutic peptides that are essential in managing various medical conditions. These peptides, typically consisting of amino acid sequences of 40 residues or less, are critical for the development of high-quality medicines. The USP provides comprehensive standards, reference materials, and analytical procedures to ensure the identity, quality, purity, and consistency of peptide therapeutics throughout their lifecycle.

The United States Pharmacopeia (USP) provides quality standards for biologics to ensure their safety, efficacy, and quality throughout the manufacturing process. These standards assist manufacturers in adhering to regulatory requirements and help safeguard public health by reducing risks associated with biologics.

Application

Glacial acetic acid USP reference standard for use in specified quality tests and assays. It is also used to prepare standard solution by using liquid chromatography coupled to a UV detector according to the general chapter of United States Pharmacopeia (USP). Based directly on official monographs published in the USP-NF, these highly characterized physical specimens are used in testing by pharmaceutical and related industries to help ensure the identity, strength, quality, and purity of peptide-based medicines.

Further information is available in the general chapter, 503- ACETIC ACID IN PEPTIDES, USP43-NF38 - 6741 of the USP (United States Pharmacopeia).

Autres remarques

This product is part of the USP Biologics program.
Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Pictogrammes

FlameCorrosion
GHS02,GHS05

Mention d'avertissement

Danger

Mentions de danger

H226,H314

Classification des risques

Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1A

Code de la classe de stockage

3 - Flammable liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

102.2 °F - closed cup

Point d'éclair (°C)

39 °C - closed cup

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Certificats d'analyse (COA)

Lot/Batch Number

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Isoamyl acetate ≥95%, FCC, FG

Sigma-Aldrich

W205508

Isoamyl acetate

Acide acétique glacial, ≥99.99% trace metals basis

Sigma-Aldrich

338826

Acide acétique

Hypochlorite de sodium solution reagent grade, available chlorine 10-15 %

Sigma-Aldrich

425044

Hypochlorite de sodium solution

Acide acétique Meets ACS Specifications, Meets Reagent Specifications for testing USP/NF monographs GR ACS

Supelco

AX0073

Acide acétique

Acide acétique glacial, ACS reagent, ≥99.7%

Sigma-Aldrich

695092

Acide acétique

Ilse Cleenwerck et al.
International journal of food microbiology, 125(1), 2-14 (2008-02-02)
Acetic acid bacteria are Gram-negative, obligate aerobic bacteria that have the ability to incompletely oxidize alcohols or sugars to organic acids as end products. They are widespread in nature and most of them are capable to oxidize ethanol as substrate
Takashi Taniguchi et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(2), 517-526 (2014-11-12)
Fli-1, a potential predisposing factor for systemic sclerosis (SSc), is constitutively down-regulated in the lesional skin of patients with SSc by an epigenetic mechanism. To investigate the impact of Fli-1 deficiency on the induction of an SSc phenotype in various
Katharine Trenholme et al.
Antimicrobial agents and chemotherapy, 58(7), 3666-3678 (2014-04-16)
Therapies to prevent transmission of malaria parasites to the mosquito vector are a vital part of the global malaria elimination agenda. Primaquine is currently the only drug with such activity; however, its use is limited by side effects. The development
Isabelle Brunet et al.
The Journal of clinical investigation, 124(7), 3230-3240 (2014-06-18)
Autonomic sympathetic nerves innervate peripheral resistance arteries, thereby regulating vascular tone and controlling blood supply to organs. Despite the fundamental importance of blood flow control, how sympathetic arterial innervation develops remains largely unknown. Here, we identified the axon guidance cue
Teagen D Quilichini et al.
The Plant cell, 26(11), 4483-4498 (2014-11-22)
Pollen grains are encased by a multilayered, multifunctional wall. The sporopollenin and pollen coat constituents of the outer pollen wall (exine) are contributed by surrounding sporophytic tapetal cells. Because the biosynthesis and development of the exine occurs in the innermost
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