WH0005997M1

Monoclonal Anti-RGS2 antibody produced in mouse

clone 4C4, purified immunoglobulin, buffered aqueous solution

• Synonyme(s) : Anti-G0S8, Anti-regulator of G-protein signalling 2, 24kDa
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: mouse
• Niveau de qualité: 100
• Conjugué: unconjugated
• Forme d'anticorps: purified immunoglobulin
• Type de produit anticorps: primary antibodies
• Clone: 4C4, monoclonal
• Forme: buffered aqueous solution
• Espèces réactives: human
• Technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable; indirect ELISA: suitable; western blot: 1-5 μg/mL
• Isotype: IgG2aκ
• Numéro d'accès GenBank: BC007049
• Numéro d'accès UniProt: P41220
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... RGS2(5997)

Description

Description générale

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. (provided by RefSeq)

Regulator of G-protein signaling 2 (RGS2) or G0/G1 switch regulatory gene 8 (GOS8) protein belongs to the regulators of G-protein signaling (RGS) protein family of GTPase accelerating proteins (GAPs). Its mRNA expression is mainly seen in the brain, heart, lung, placenta, kidney, intestine, lymphocytes, and testis. RGS2 is located in the nucleus and the plasma membrane. RGS2 gene is located on human chromosome 1q31.2.

Immunogène

RGS2 (AAH07049, 111 a.a. ~ 211 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
EFWLACEDFKKTKSPQKLSSKARKIYTDFIEKEAPKEINIDFQTKTLIAQNIQEATSGCFTTAQKRVYSLMENNSYPRFLESEFYQDLCKKPQITTEPHAT

Actions biochimiques/physiologiques

Regulator of G-protein signaling 2 (RGS2) or G0/G1 switch regulatory gene 8 (GOS8) can decrease the activity of G protein through its GTPase actions. It acts as a GTPase activating protein (GAP) for G-protein (Gi). It might bind to adenylate cyclase to play an inhibitory role in Gs-mediated adenylate cyclase activity. RGS2 can block the proliferation of androgen-independent prostate cancer cells by inhibiting both constitutively activated extracellular signal-regulated kinases (ERKs) and androgen-independent androgen receptor (AR) activity. RGS2 is expressed at a high level in several solid breast cancers. Variation in the RGS2 gene might be involved in the development of anxiety in humans.

Forme physique

Solution in phosphate buffered saline, pH 7.4

Informations légales

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Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)