SML4090

TH-Z93

≥98% (HPLC)

• Synonyme(s) : (((4-(Hexyloxy)pyridin-2-yl)amino)methylene)bis(phosphonic acid), P,P′-[[[4-(Hexyloxy)-2-pyridinyl]amino]methylene]bis[phosphonic acid]
• Formule empirique (notation de Hill) : C₁₂H₂₂N₂O₇P₂
• Numéro CAS: 2260887-09-8
• Poids moléculaire : 368.26
• Code UNSPSC : 12352200

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: soluble (H2O + 1 drop 5M NaOH, 2 mg/mL, clear)
• Température de stockage: 2-8°C

Description

Actions biochimiques/physiologiques

Potent mevalonate (MVA) pathway farnesyl diphosphate synthase (FPPS) inhibitor that stimulates immune responses in vivo.


TH-Z93 is a potent farnesyl diphosphate synthase (FPPS) inhibitor (IC50 = 90 nM) that stimulates immune responses by blocking the mevalonate (MVA) pathway-mediated post-translational protein geranylgeranylation. When co-administered with antigen in mice in vivo, TH-Z93 triggers strong adjuvant responses, increasing OVA-specific antibody titres (in mice immunized with 100 μg OVA + 100 μg TH-Z93) and protects against death caused by live influenza virus PR8 challenge (in mice immunized with 5 μg PR8 HA1 subunit containing TH-Z93). TH-Z93 adjuvant efficacy is blocked by GGPP and synergized with HMG-CoA inhibitor simvastatin.