SML4064

Ac-Abu-Tle-Leu-Gln-AFC

≥95% (HPLC)

• Synonyme(s) : Ac-Abu-Tle-LQ-AFC (Abu=2-Aminobutyrate, Tle=t-Butylglycine, AFC = 4-trifluoromethylcoumaryl-7-amide), Ac-QS1-AFC, Acetyl-L-α-aminobutyroyl-L-tert-leucyl-L-leucyl-L-glutamine-α-(4-trifluoromethylcoumaryl-7-amide)
• Formule empirique (notation de Hill) : C₃₄H₄₆F₃N₅O₈
• Poids moléculaire : 709.75
• Code UNSPSC : 12352200

Propriétés

• Niveau de qualité: 100
• Essai: ≥95% (HPLC)
• Forme: (Powder or Lyophilized powder or film)
• Conditions de stockage: desiccated
• Couleur: white to off-white
• Température de stockage: -10 to -25°C
• Chaîne SMILES: CC(N[C@H](C(N[C@H](C(C[C@H](C(N[C@H](C(NC1=CC2=C(C=C1)C(C(F)(F)F)=CC(O2)=O)=O)CCC(N)=O)=O)CC(C)C)=O)C(C)(C)C)=O)CC)=O
• InChI: 1S/C34H46F3N5O8/c1-8-23(39-18(4)43)31(48)42-29(33(5,6)7)25(44)14-19(13-17(2)3)30(47)41-24(11-12-27(38)45)32(49)40-20-9-10-21-22(34(35,36)37)16-28(46)50-26(21)15-20/h9-10,15-17,19,23-24,29H,8,11-14H2,1-7H3,(H2,38,45)(H,39,43)(H,40,49)(H,41,47)(H,42,48)/t19
• Clé InChI: VWVFVJSQWAXHGY-RYRALHHHSA-N

Description

Actions biochimiques/physiologiques

Kinetically preferred fluorogenic substrate for detecting SARS-CoV and SARS-CoV-2 main proteases (Mpro; 3CLpro) activity (ex 380+/-20 nm, em 500+/-20 nm).
Ac-QS1-AFC or Ac-Abu-Tle-Leu-Gln-AFC (Abu = Aminobutyrate; Tle = t-Butylglycine; AFC= 7-amino-4-trifluoromethyl coumarin) is a kinetically preferred fluorogenic substrate for the detection of SARS-CoV and SARS-CoV-2 main protease (Mpro; 3CLpro) activity. Mpro cleavage results in the release of the C-terminal AFC and increased fluorescence (ex 380+/-20 nm, em 500+/-20 nm).

Attention

Hygroscopic

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable