SML3323

MS9715

≥98% (HPLC)

• Synonyme(s) : (2S,4R)-1-((S)-2-(9-(4-((4-(5-(7-fluoroquinolin-4-yl)-1-methyl-1H-imidazol-4-yl)-3,5-dimethylbenzyl)amino)butanamido)nonanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
• Formule empirique (notation de Hill) : C₅₈H₇₄FN₉O₅S
• Poids moléculaire : 1028.33
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.32

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Couleur: white to beige
• Solubilité: DMSO: 2 mg/mL, clear
• Température de stockage: 2-8°C
• Chaîne SMILES: CC1=C(C(C)=CC(CNCCCC(NCCCCCCCCC(N[C@H](C(N2[C@@H](C[C@H](C2)O)C(N[C@H](C3=CC=C(C=C3)C4=C(N=CS4)C)C)=O)=O)C(C)(C)C)=O)=O)=C1)C5=C(N(C=N5)C)C6=CC=NC7=C6C=CC(F)=C7
• InChI: 1S/C58H74FN9O5S/c1-36-28-40(29-37(2)51(36)52-53(67(8)34-63-52)46-24-27-61-47-30-43(59)22-23-45(46)47)32-60-25-15-17-49(70)62-26-14-12-10-9-11-13-16-50(71)66-55(58(5,6)7)57(73)68-33-44(69)31-48(68)56(72)65-38(3)41-18-20-42(21-19-41)54-39(4)64-35-74-54/h18-
• Clé InChI: RWXCSOWWDBANDF-LPFSXYLXSA-N

Description

Actions biochimiques/physiologiques

MS9715 is a potent and highly selective degrader (PROTAC) of NSD3 (Nuclear receptor binding SET domain protein 3) that effectively depletes NSD3 and the associated cMyc oncogenic node. MS9715 comprised of NSD3 antagonist BI-9321 linked to an E3 ligase VHL ligand. It potently inhibits growth of NSD3-dependent hematological cancer cells.

Potent and highly selective degrader (PROTAC) of NSD3 that effectively depletes NSD3 and the associated cMyc oncogenic node

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3