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Principaux documents

SCP0052

Sigma-Aldrich

[Glu11]-Amyloid β 1-16

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About This Item

Formule empirique (notation de Hill) :
C84H119N27O28
Poids moléculaire :
1955.01
Code UNSPSC :
12352209
Nomenclature NACRES :
NA.32

Essai

≥95% (HPLC)

Forme

lyophilized

Composition

Peptide Content, ≥70%

Conditions de stockage

protect from light

Température de stockage

−20°C

Amino Acid Sequence

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys

Application

Amyloid β (Aβ) refers to peptides derived from Amyloid precursor protein that vary in length from 36-43 amino acids. Aβ(s) peptides, their peptide fragments and mutated fragments are used to study a wide range of metabolic and regulatory functions including activation of kinases, regulation of cholesterol transport, function as a transcription factor, and regulators of inflammation. Aβ(s) peptides and their peptide fragments are also used to study oxidative stress, metal binding and mechanisms of protein cross-linking in the context of diseases such as Alzheimer′s disease and neurodegeneration.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
CC1101

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Youssef El Khoury et al.
The journal of physical chemistry. B, 115(49), 14812-14821 (2011-10-27)
Alzheimer's disease is a neurodegenerative disorder in which the formation of amyloid-β (Aβ) aggregates plays a causative role. There is ample evidence that Cu(II) can bind to Aβ and modulate its aggregation. Moreover, Cu(II) bound to Aβ might be involved
Craig S Atwood et al.
Brain research. Brain research reviews, 43(1), 1-16 (2003-09-23)
Although much maligned, the amyloid-beta (Abeta) protein has been shown to possess a number of trophic properties that emanate from the protein's ability to bind Cu, Fe and Zn. Abeta belongs to a group of proteins that capture redox metal
Antonio Verdoliva et al.
Human vaccines, 6(11), 936-947 (2010-10-29)
Over the past few years, new ways of fighting Alzheimer's disease have emerged based on stimulating the immunitary defence system of the patients. To avoid toxicity and autoimmune response related to the Aβ[1-42] peptide immunotherapy, in the last decade a

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