SAB6010095

Anti-phospho-MLKL (S358) antibody, clone 4A6, Rabbit Monoclonal

recombinant, expressed in HEK293F cells

• Synonyme(s) : Mixed lineage kinase domain-like protein, hMLKL, MLKL
• Code UNSPSC : 12352203

Propriétés

• Produit recombinant: expressed in HEK 293 F cells
• Niveau de qualité: 100
• Conjugué: unconjugated
• Type de produit anticorps: primary antibodies
• Clone: 4A6, recombinant monoclonal
• Forme: liquid
• Poids mol.: 150 kDa
• Produit purifié par: affinity chromatography
• Espèces réactives: human
• Concentration: 1.6mg/ml
• Technique(s): ELISA: 2000:10000; flow cytometry: 1:50-1:200; immunofluorescence: 1:50-1:200; immunohistochemistry: 1:50-1:200
• Isotype: IgG
• Numéro d'accès UniProt: Q8NB16
• Conditions d'expédition: wet ice
• Température de stockage: -10 to -25°C
• Modification post-traductionnelle de la cible: phosphorylation (pSer358)

Description

Description générale

Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.

Immunogène

A synthesized peptide derived from human Phospho-MLKL (S358)

Séquence

344-389aa

Forme physique

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Stockage et stabilité

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable