SAB6010005

Anti-phospho-MAPT (S404) antibody, clone 11H10, Rabbit Monoclonal

recombinant, expressed in HEK293F cells

• Synonyme(s) : Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau), MAPT, MAPTL MTBT1 TAU
• Code UNSPSC : 12352203

Propriétés

• Produit recombinant: expressed in HEK 293 F cells
• Niveau de qualité: 100
• Conjugué: unconjugated
• Type de produit anticorps: primary antibodies
• Clone: 11H10, recombinant monoclonal
• Forme: liquid
• Poids mol.: 150 kDa
• Produit purifié par: affinity chromatography
• Espèces réactives: human
• Concentration: 0.4mg/ml
• Technique(s): ELISA: 2000:10000; flow cytometry: 1:50-1:200; immunofluorescence: 1:50-1:200; immunohistochemistry: 1:50-1:200
• Isotype: IgG
• Numéro d'accès UniProt: P10636
• Conditions d'expédition: wet ice
• Température de stockage: -10 to -25°C
• Modification post-traductionnelle de la cible: phosphorylation (pSer404)

Description

Description générale

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Immunogène

A synthesized peptide derived from Human MAPT

Séquence

ST-pS-PS

Forme physique

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Stockage et stabilité

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable