SAB1401851
Anti-PNPLA3 antibody produced in rabbit
purified immunoglobulin, buffered aqueous solution
Synonyme(s) :
ADPN, C22orf20, iPLA(2)epsilon
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About This Item
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
rabbit
Niveau de qualité
Conjugué
unconjugated
Forme d'anticorps
purified immunoglobulin
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
buffered aqueous solution
Espèces réactives
mouse, human
Technique(s)
western blot: 1 μg/mL
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
dry ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... PNPLA3(80339)
Description générale
Patatin like phospholipase domain containing 3 (PNPLA3) gene is mapped to human chromosome 22q13.3. The protein encoded by this gene is a triacylglycerol lipase.
Immunogène
PNPLA3 (AAH65195.1, 1 a.a. ~ 481 a.a) full-length human protein.
Sequence
MYDAERGWSLSFAGCGFLGFYHVGATRCLSEHAPHLLRDARMLFGASAGALHCVGVLSGIPLEQTLQVLSDLVRKARSRNIGIFHPSFNLSKFLRQGLGKCLPANVHQLISGKIGISLTRVSDGENVLVSDFRSKDEVVDALVCSCFMPFYSGLIPPSFRGVRYVDGGVSDNVPFIDAKTTITVSPFYGEYDICPKVKSTNFLHVDITKLSLRLCTGNLYLLSRAFVPPDLKVLGEICLRGYLDAFRFLEEKGICNRPQPGLKSSSEGMDPEVAMPSWANMSLDSSPESAALAVRLEGDELLDHLRLSILPWDESILDTLSPRLATALSEEMKDKGGYMSKICNLLPIRIMSYVMLPCTLPVESAIAIVQRLVTWLPDMPDDVLWLQWVTSQVFTRVLMCLLPASRSQMPVSSQQASPCTPEQDWPCWTPCSPEGCPAETKAEATPRSILRSSLNFFLGNKVPAGAEGLSTFPSFSLEKSL
Sequence
MYDAERGWSLSFAGCGFLGFYHVGATRCLSEHAPHLLRDARMLFGASAGALHCVGVLSGIPLEQTLQVLSDLVRKARSRNIGIFHPSFNLSKFLRQGLGKCLPANVHQLISGKIGISLTRVSDGENVLVSDFRSKDEVVDALVCSCFMPFYSGLIPPSFRGVRYVDGGVSDNVPFIDAKTTITVSPFYGEYDICPKVKSTNFLHVDITKLSLRLCTGNLYLLSRAFVPPDLKVLGEICLRGYLDAFRFLEEKGICNRPQPGLKSSSEGMDPEVAMPSWANMSLDSSPESAALAVRLEGDELLDHLRLSILPWDESILDTLSPRLATALSEEMKDKGGYMSKICNLLPIRIMSYVMLPCTLPVESAIAIVQRLVTWLPDMPDDVLWLQWVTSQVFTRVLMCLLPASRSQMPVSSQQASPCTPEQDWPCWTPCSPEGCPAETKAEATPRSILRSSLNFFLGNKVPAGAEGLSTFPSFSLEKSL
Application
Anti-PNPLA3 antibody produced in rabbit has been used in western blotting.
Actions biochimiques/physiologiques
PNPLA3 (patatin like phospholipase domain containing 3) involves lipogenic transacetylase activity. Variation in PNPLA3 (patatin like phospholipase domain containing 3) is known to increase the fat content of hepatocytes, thereby promoting the severity of nonalcoholic liver disease. The gene is found to be associated with hepatic steatosis, liver fibrosis and cancer. PNPLA3 might be involved in energy homeostasis. PNPLA3 mediates triacylglycerol hydrolysis in adipocytes and is involved in the balance of energy usage cum storage in adipocytes.
PNPLA3 mediates triacylglycerol hydrolysis in adipocytes and is involved in the balance of energy usage cum storage in adipocytes.
Forme physique
Solution in phosphate buffered saline, pH 7.4
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
12 - Non Combustible Liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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PNPLA3 and RNF7 Gene Variants are Associated with the Risk of Developing Liver Fibrosis and Cirrhosis in an Eastern European Population.
Kupcinskas J
Journal of Gastrointestinal and Liver Diseases : JGLD, 26(1), 37-43 (2017)
Takahisa Kawaguchi et al.
PloS one, 7(6), e38322-e38322 (2012-06-22)
Nonalcoholic fatty liver disease (NAFLD) includes a broad range of liver pathologies from simple steatosis to cirrhosis and fibrosis, in which a subtype accompanying hepatocyte degeneration and fibrosis is classified as nonalcoholic steatohepatitis (NASH). NASH accounts for approximately 10-30% of
Cyanidin-3-O-beta-glucoside protects against liver fibrosis induced by alcohol via regulating energy homeostasis and AMPKautophagy signaling pathway
Wan T, et al.
Journal of functional foods, 37, 16-24 (2017)
Juozas Kupcinskas et al.
Journal of gastrointestinal and liver diseases : JGLD, 26(1), 37-43 (2017-03-25)
Genome-wide association studies have revealed an association between the risk of developing liver fibrosis or cirrhosis and the single nucleotide polymorphisms (SNPs) of the PNPLA3, RNF7, MERTK and PCSK7 genes. We aimed to validate these results in an Eastern European
Relationships between Genetic Variations of PNPLA3, TM6SF2 and Histological Features of Nonalcoholic Fatty Liver Disease in Japan.
Akuta N
Gut and Liver, 10(3), 437-445 (2016)
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