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Principaux documents

RAB1515

Sigma-Aldrich

Human IL-12 R beta 2 ELISA

for serum, plasma and cell culture supernatants

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About This Item

Code UNSPSC :
41116158
Nomenclature NACRES :
NA.32

Espèces réactives

human

Technique(s)

ELISA: suitable

Entrée

sample type plasma
sample type cell culture supernatant(s)
sample type serum

assay range

inter-assay cv: <12%
intra-assay cv: <10%

Conditions d'expédition

wet ice

Température de stockage

−20°C

Informations sur le gène

human ... IL12RB2(3595)

Catégories apparentées

Description générale

The IL12RB2 (interleukin 12 receptor subunit β 2) gene is mapped to human chromosome 1p31.3 and codes for the β2 chain (130 kDa) of IL-12 receptor.
This ELISA antibody pair detects human IL-12 R beta 2. Other species not yet determined.

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.

Actions biochimiques/physiologiques

Il12rb2 (interleukin 12 receptor subunit β 2) stimulates the release of interferon γ and Th1 (T helper cell 1) cell differentiation, as a part of autoimmune response. Il12rb2′s major function is associated with cell mediated immune system. In mice model, deletion of L12RB2 gene is associated with autoimmune and malignant disorders.

Autres remarques

A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.

Pictogrammes

Corrosion
GHS05

Mention d'avertissement

Warning

Mentions de danger

H290

Conseils de prudence

P234 - P390

Classification des risques

Met. Corr. 1

Code de la classe de stockage

8A - Combustible corrosive hazardous materials

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

Identification of susceptibility SNPs in IL10 and IL23R-IL12RB2 for Behcet's disease in Han Chinese.
Yu H, et al.
The Journal of Allergy and Clinical Immunology, 139(2), 621-627 (2017)
IL12RB2 Polymorphisms correlate with risk of lung adenocarcinoma.
Prigione I, et al.
Immunobiol., 221(2), 291-299 (2016)
Association study of rs924080 and rs11209032 polymorphisms of IL23R-IL12RB2 in a Northern Chinese Han population with Behcet?s disease.
Qin X, et al.
Human immunology, 77(12), 1284-1290 (2016)
An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation.
Roberts A R, et al.
Annals of the Rheumatic Diseases (2016)
Nahoko Kato-Kogoe et al.
Immunogenetics, 68(1), 55-65 (2015-11-11)
Interleukin 12 receptor β chain (IL12RB2) is a crucial regulatory factor involved in cell-mediated immune responses, and genetic variants of the gene encoding IL12RB2 are associated with susceptibility to various immune-related diseases. We previously demonstrated that haplotypes with single nucleotide

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