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Principaux documents

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C9369

Sigma-Aldrich

CCT007093

≥98% (HPLC), powder, yellow

Synonyme(s) :

(2E,5E)-2,5-Bis(2-thienylmethylene)-cyclopentanone

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About This Item

Formule empirique (notation de Hill) :
C15H12OS2
Numéro CAS:
176957-55-4
Poids moléculaire :
272.39
Numéro MDL:
MFCD00121546
Code UNSPSC :
12352200
ID de substance PubChem :
329775204
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Essai

≥98% (HPLC)

Forme

powder, yellow

Solubilité

DMSO: >3 mg/mL

Température de stockage

2-8°C

Chaîne SMILES 

O=C1\C(CC\C1=C/c2cccs2)=C\c3cccs3

InChI

1S/C15H12OS2/c16-15-11(9-13-3-1-7-17-13)5-6-12(15)10-14-4-2-8-18-14/h1-4,7-10H,5-6H2/b11-9+,12-10+

Clé InChI

KPFZCKDPBMGECB-WGDLNXRISA-N

Application

CCT007093 has been used as a wild-type p53-induced phosphatase (Wip1) inhibitor to study its effect on skin keratinocytes, under ultra-violet (UV) stress conditions. It has also been used as a Wip1 inhibitor in time course inhibition assay to evaluate the effect of Wip1 inhibition on expression of AKT serine/threonine kinase 1(Akt1) and glycogen synthase kinase-3β (GSK-3β)and the phosphorylation of GSK-3β at serine 9 (Ser9) and Akt at Ser473.

Actions biochimiques/physiologiques

CCT007093 inhibits the growth of cancer cell lines (MCF-7, KPL-1, and MCF-3B) that overexpress protein phosphatase, Mg2+/Mn2+ dependent 1D (PPM1D). It induces cancer cell death via the activation of p38 kinase activity.
CCT007093 is an effective PPM1D inhibitor that selectively reduces viability of human tumour cell lines.
CCT007093 is an effective protein phosphatase, Mg2+/Mn2+ dependent, 1D (PPM1D) inhibitor that selectively reduces viability of human tumour cell lines.

Caractéristiques et avantages

This compound is featured on the Phosphoprotein Phosphatases (Serine/Threonine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319,H335

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number
013M4611V
088K46132
088K46131
088K4613

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Sheng Yin et al.
Oncotarget, 7(20), 29359-29370 (2016-04-29)
Inactivation of p53 greatly contributes to serous ovarian cancer, while the role of the wild-type p53 induced phosphatase 1 (Wip1) is quite unclear. In this study, by silencing or overexpression of Wip1, we found that Wip1 suppressed ovarian cancer cell
Joshua A Bauer et al.
Breast cancer research : BCR, 12(3), R41-R41 (2010-06-26)
Paclitaxel is a widely used drug in the treatment of patients with locally advanced and metastatic breast cancer. However, only a small portion of patients have a complete response to paclitaxel-based chemotherapy, and many patients are resistant. Strategies that increase
S Rayter et al.
Oncogene, 27(8), 1036-1044 (2007-08-19)
The PPM1D gene is aberrantly amplified in a range of common cancers and encodes a protein phosphatase that is a potential therapeutic target. However, the issue of whether inhibition of PPM1D in human tumour cells that overexpress this protein compromises
J-Y Song et al.
Cell death & disease, 4, e744-e744 (2013-08-03)
Wild-type p53-induced phosphatase 1 (Wip1) is a p53-inducible serine/threonine phosphatase that switches off DNA damage checkpoint responses by the dephosphorylation of certain proteins (i.e. p38 mitogen-activated protein kinase, p53, checkpoint kinase 1, checkpoint kinase 2, and uracil DNA glycosylase) involved

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