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C8982

Sigma-Aldrich

αAcide α-cyano-4-hydroxycinnamique

suitable for MALDI-TOF MS

Synonyme(s) :

αα-CCA, αα-CHCA, αα-Cyano, 4-HCCA, ACCA

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About This Item

Formule linéaire :
HOC6H4CH=C(CN)CO2H
Numéro CAS:
28166-41-8
Poids moléculaire :
189.17
Beilstein:
3271427
Numéro CE :
248-879-1
Numéro MDL:
MFCD00004204
Code UNSPSC :
12352106
ID de substance PubChem :
24893121
Nomenclature NACRES :
NA.21

Forme

powder

Niveau de qualité

500

Classe(s) chimique(s) de l'analyte

glycans, peptides, proteins

Pf

245-250 °C (lit.)

Adéquation

suitable for MALDI-TOF MS

Température de stockage

room temp

Chaîne SMILES 

OC(=O)\C(=C\c1ccc(O)cc1)C#N

InChI

1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)/b8-5+

Clé InChI

AFVLVVWMAFSXCK-VMPITWQZSA-N

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Catégories apparentées

Description générale

α-Cyano-4-hydroxycinnamic acid (CHCA) is specially purified and qualified as a matrix for peptide MALDI-MS (matrix assisted laser desorption ionization-mass spectrometry) calibration standards. CHCA enhances ionization of protein or peptide standards and samples in matrix assisted laser desorption ionization (MALDI) mass spectrometers.
It is also available as part of our ProteoMass™ MALDI calibration kits (MS-CAL1 and MS-CAL3).

Application

α-Cyano-4-hydroxycinnamic acid has been used as a matrix for MALDI-TOF MS (matrix assisted laser desorption ionization-time of flight mass spectrometry) analysis. The matrix has also been used for sample preparation.

Conditionnement

Bottomless glass bottle. Contents are inside inserted fused cone.

Informations légales

ProteoMass is a trademark of Sigma-Aldrich Co. LLC

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

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ProteoMass™ ACTH Fragment 18-39 MALDI-MS Standard, vial of 10 nmol, monoisotopic mol wt 2,464.1989 Da

I6154

ProteoMass™ Insulin chain B oxidized MALDI-MS Standard, vial of 10 nmol

I6279

Insuline from bovine pancreas, vial of 10 nmol, monoisotopic mol wt 5,729.6087 Da

A8471

ProteoMass™ Albumin MALDI-MS Standard, vial of 10 nmol, average mol wt 66,429.09 Da by calculation

A9096

ProteoMass™ Aldolase MALDI-MS Standard, vial of 10 nmol, average mol wt 39,211.28 Da by calculation

A8846

ProteoMass™ Angiotensin II MALDI-MS Standard, vial of 10 nmol

A8971

ProteoMass™ Apomyoglobin MALDI-MS Standard, vial of 10 nmol, (M+H+) 16,952.27 Da by calculation

B4181

ProteoMass™ Bradykinin Fragment 1-7 MALDI-MS Standard, vial of 10 nmol, monoisotopic mol wt 756.3997 Da

MSCAL1

ProteoMass™ Peptide and Protein MALDI-MS Calibration Kit, Peptide and Protein MALDI MS Calibration Standard

MSCAL2

ProteoMass™ Peptide MALDI-MS Calibration Kit, Peptide MALDI MS Calibration Standard

MSCAL3

ProteoMass™ Protein MALDI-MS Calibration Kit, Protein MALDI MS Calibration Standard

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3-Hydroxypicolinic acid, ≥99.0% (HPLC)

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2-(4-Hydroxyphenylazo)benzoic acid, ≥99.5%

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Sinapic acid, ≥99.0% (T)

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MALDI validation set polystyrene Mp ~700 - 70 000, certified reference material

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2′,6′-Dihydroxyacetophenone, ≥99.5%

91928

2′,4′,6′-Trihydroxyacetophenone monohydrate, ≥99.5%

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trans-2-[3-(4-tert-Butylphenyl)-2-methyl-2-propenylidene]malononitrile, ≥99.0% (HPLC)

60018

Caffeic acid, suitable for matrix substance for MALDI-MS, ≥99.0% (HPLC)

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(N-Succinimidyloxycarbonylmethyl)tris(2,4,6-trimethoxyphenyl)phosphonium bromide, ≥98.5%

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Ferulic acid, ≥99.0% (HPLC)

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2,5-Dihydroxybenzoic acid, >99.0% (HPLC)

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αAcide α-cyano-4-hydroxycinnamique, suitable for matrix substance for MALDI-MS, ≥99.0% (HPLC)

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α(2→3,6,8,9) Neuraminidase from Arthrobacter ureafaciens, Proteomics Grade, suitable for MALDI-TOF MS

39468

αAcide α-cyano-4-hydroxycinnamique, Ultra pure

39319

2,5-Dihydroxybenzoic acid, ≥99.5% (HPLC), Ultra pure

49508

Sinapic acid, ≥99.5%, Ultra pure

50862

Super-DHB, suitable for matrix substance for MALDI-MS, ≥99.0%

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2′,3′-Dideoxycytidine 5′-triphosphate sodium salt solution, suitable for MALDI-MS, ≥98.0% (HPLC)

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3′-Deoxythymidine 5′-triphosphate sodium salt solution, BioChemika, puriss. p.a., suitable for MALDI-MS, ≥98.0% (HPLC)

MS0100

ProteoMass™ Guanidination Kit, For improving MALDI-MS sensitivity and peptide sequence coverage

MSCAL4

ProteoMass™ MALDI Calibration Kit for Exactive Series MS, LTQ XL and LTQ Hybrids, MALDI MS Calibration Standard

92817

9-Aminoacridine, ≥99.5% (HPLC)

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1,5-Diaminonaphthalene, ≥99.0% (HPLC)

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Micro-Array for Mass Spectrometry (MAMS), for single cell analysis

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4-Chloro-α-cyanocinnamic acid, ≥95.0% (HPLC)

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4-Bromo-α-cyanocinnamic acid, ≥95.0% (HPLC)

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α-Cyano-4-fluorocinnamic acid, ≥95.0% (HPLC)

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α-Cyano-2,3,4,5,6-pentafluorocinnamic acid, ≥95.0% (HPLC)

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4-Chloro-α-cyanocinnamic acid - α-Cyano-2,4-difluorocinnamic acid mixture, ≥95.0% (sum of both components, HPLC)

68914

4-Bromo-α-cyanocinnamic acid - 4-Chloro-α-cyanocinnamic acid mixture, ≥95.0% (sum of both components, HPLC)

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4-Aminoquinaldine, ≥99.0% (HPLC)

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Curcumin, ≥99.5% (HPLC)

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(E)-2-Cyano-3-(2-naphthyl)acrylic acid, ≥98.0% (HPLC)

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(2E)-3-(9-Anthryl)-2-cyanoacrylic acid, ≥97.0% (HPLC)

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Anthranilamide, ≥99.0% (HPLC)

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9-Nitroanthracene, ≥98.5% (HPLC)

PFS11

SpheriCal™ Mix, Peptide Low, suitable for MALDI-MS

PFS31

SpheriCal™ Aqua, Peptide Medium, suitable for MALDI-MS

PFS32

SpheriCal™ Aqua, Peptide High, suitable for MALDI-MS

PFS20

SpheriCal™ Neat, Peptide Low, suitable for MALDI-MS

PFS21

SpheriCal™ Neat, Peptide Medium, suitable for MALDI-MS

PFS22

SpheriCal™ Neat, Peptide High, suitable for MALDI-MS

PFS23

SpheriCal™ Neat, Protein Low, suitable for MALDI-MS

PFS30

SpheriCal™ Aqua, Peptide Low, suitable for MALDI-MS

69028

4-Phenyl-α-cyanocinnamamide, ≥98.5% (HPLC)

900666

Bruker standard solvent, suitable for MALDI-MS, 50% ACN + 47.5% H2O + 2.5% TFA

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H317

Classification des risques

Skin Sens. 1B

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number
BCCG3811
BCCC8081
SLCD2208
SLCB9558
BCBZ5249

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Utilizing isotope dilution-matrix-assisted laser desorption ionization-time of flight mass spectrometry as a reference procedure for the radioimmunoassay of serum thyroxine.
Tyan YC, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 420, 99-103 (2013)
a-Cyano-4-hydroxycinnamic acid as a matrix for matrixassisted laser desorption mass spectromtry.
Beavis RC, et al.
Journal of Mass Spectrometry : Jms, 27, 156-158 (1992)
MALDI-TOF MS sample preparation by using alkanethiolate self-assembled monolayers: A preliminary application for protein sample analysis.
Tyan Y-C, et al.
International Journal of Mass Spectrometry, 262, 67-72 (2007)
The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), a-, and ?-melanocyte stimulating hormone (a-MSH, and ?-MSH), and the conserved core motif HFRW.
N?hr AC, et al.
Neurochemistry International, 102, 105-113 (2017)
J Gobom et al.
Analytical chemistry, 73(3), 434-438 (2001-02-24)
We present a new MALD1 sample preparation technique for peptide analysis using the matrix alpha-cyano-4-hydroxy-cinnamic acid (CHCA) and prestructured sample supports. The preparation integrates sample purification, based on the affinity of microcrystalline CHCA for peptides, thereby simplifying the analysis of
Afficher tous les articles scientifiques apparentés

Articles

Methods and Matrices for Mass Spectrometry of Glycans

Glycosylation is known to have profound influence on various physiochemical, cellular and biological functions of proteins. Alterations in this modification are known to affect the immune system and have been associated with various pathological states such as cancer, rheumatoid arthritis, and inflammatory diseases.

Methods and Matrices for Mass Spectrometry of Glycans

Glycosylation is known to have profound influence on various physiochemical, cellular and biological functions of proteins. Alterations in this modification are known to affect the immune system and have been associated with various pathological states such as cancer, rheumatoid arthritis, and inflammatory diseases.

Methods and matrices for mass spectrometry of glycans

Mass Spectrometry of Glycans, method comparison and products

Protocoles

Mass Spectrometry of Glycans

Mass Spectrometry of Glycans

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

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