C6473
Monoclonal Anti-CXCR3 antibody produced in mouse
clone 49801.111, purified immunoglobulin, lyophilized powder
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About This Item
Produits recommandés
Source biologique
mouse
Niveau de qualité
Conjugué
unconjugated
Forme d'anticorps
purified immunoglobulin
Type de produit anticorps
primary antibodies
Clone
49801.111, monoclonal
Forme
lyophilized powder
Espèces réactives
human
Technique(s)
flow cytometry: suitable
Isotype
IgG1
Numéro d'accès UniProt
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... CXCR3(2833)
mouse ... Cxcr3(12766)
Catégories apparentées
Description générale
Chemokine receptor CXCR3 also refers as IP -10 or Mig receptor is a Gαi protein-coupled receptor and is highly expressed by IL-2-activated T lymphocytes (Th1). It facilitates calcium mobilization and chemotaxis. It also plays a pivotal role in wound healing. Monoclonal Anti-CXCR3 antibody can be used in flow cytometry for the Identification of CXCR-3. Mouse anti-CXCR3 antibody reacts specifically with CXCR-3 transfected cells but not with the parent cell line. The product has shown no cross-reactivity with human CXCR-1, CXCR-2 and CXCR-4.
Spécificité
The antibody reacts with human CXCR3 transfectant cells and not the parent cell line. It has no cross-reactivity with CXCR1, CXCR2, or CXCR4.
Immunogène
human CXCR3 transfected NSO mouse myeloma cells.
Application
Monoclonal Anti-CXCR3 antibody can be used as a positive control in immunohistochemical staining.
Forme physique
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
Notes préparatoires
Purified using protein G.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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Cecelia C Yates et al.
The American journal of pathology, 171(2), 484-495 (2007-06-30)
Replacement of wounded skin requires the initially florid cellular response to abate and even regress as the dermal layer returns to a relatively paucicellular state. The signals that direct this "stop and return" process have yet to be deciphered. CXCR3
S Kobayashi et al.
Rheumatology (Oxford, England), 47(9), 1317-1322 (2008-07-12)
Environmental factors are involved in RA pathogenesis and epidemiological studies have suggested that smoking is an environmental risk factor for RA. The 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is one of the major toxic components in cigarettes. To clarify the biological effects of smoking
Changzheng Du et al.
BMJ open, 4(8), e005012-e005012 (2014-09-19)
The prognostic significance of chemokine receptors in stage I/II colon cancer is unclear. We assessed the prognostic value of chemokine receptor CXCR3 and CXCR4 in stage I/II colon cancer. 145 patients with stage I/II colon cancer who underwent curative surgery
Francesca Bellora et al.
European journal of immunology, 44(6), 1814-1822 (2014-02-11)
We analyzed the functional outcome of the interaction between tumor-associated macrophages (TAMs) and natural killer (NK) cells. TAMs from ascites of ovarian cancer patients displayed an alternatively activated functional phenotype (M2) characterized by a remarkably high frequency and surface density
Tsung-Han Wu et al.
Cellular immunology, 290(1), 107-115 (2014-06-25)
We developed an in vitro model to evaluate the effect of products secreted from different colorectal cancer (CRC) cell lines on specific phenotypic switching and functional alterations in THP-1 cells. We co-cultured the human monocytic cell line, THP-1, or phorbol-12-myristate-13-acetate
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