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17928

Sigma-Aldrich

O-Methyl-O′-succinylpolyethylene glycol 2′000

Synonyme(s) :

Polyethylene glycol, O-(Succinyl)-O′-methylpolyethylene glycol 2′000, Polyethylene glycol 2′000 monomethyl ether succinate

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About This Item

Formule linéaire :
CH3O(CH2CH2O)nCOCH2CH2COOH
Numéro CAS:
31961-02-1
Numéro MDL:
MFCD00284260
Code UNSPSC :
51171641
Nomenclature NACRES :
NA.26

Forme

powder

Niveau de qualité

100

Poids mol.

Mr ~2100

Pf

50-53 °C

Extrémité Ω

carboxylic acid

Extrémité α

methoxy

Température de stockage

−20°C

Application

Polyethylene glycol 2000 is used in the construction of biomaterials such as biopolymers, micelles and nanostructures.

Actions biochimiques/physiologiques

O-Methyl-O′-succinylpolyethylene glycol 2′000 is a modified monomethoxypolyethylene glycol (mPEG) wherein the hydroxyl groups are succinylated by succinic anhydride. This succinylated mPEG can then be used to synthesize tolerogenic mPEG conjugates of peptides. Tolerogenic peptide conjugates are very effective reagents for obtaining epitope-specific immunosuppression of antibody responses to immunopathogenic sites on multideterminant complex protein antigens.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

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Antitumor effect of liposomal histone deacetylase inhibitor-lipid conjugates in vitro.
Hattori Y, Nagaoka Y, Kubo M, et al.
Chemical & Pharmaceutical Bulletin, 59, 1389-1392 (2011)
Gulam Mustafa Hasan et al.
Journal of parasitology research, 2011, 120462-120462 (2011-07-21)
We have examined the effect of stearylamine (SA) in liposomes on the viability of Plasmodium falciparum in culture by studying the inhibition of incorporation of [(3)H]-hypoxanthine in the nucleic acid of parasites. Stearylamine in liposomes significantly inhibits the growth of
Ayman El-Sayed et al.
Journal of pharmaceutical sciences, 101(2), 879-882 (2011-11-17)
We previously reported on a stearylated INF7 peptide (str-INF7), which enhances the endosomal escape of an octaarginine (R8)-modified liposomal particle encapsulating plasmid DNA (pDNA) in a fusion-independent manner. This study examined whether this peptide derivative enhanced the endosomal escape and
Peptide/protein-polymer conjugates: synthetic strategies and design concepts.
Gauthier MA, Klok HA.
Chemical Communications (Cambridge, England), 21, 2591-2611 (2008)
Sabrina Hoffmann et al.
Immunology letters, 136(1), 13-20 (2010-11-30)
T-cell recognition of peptide-MHC complexes on APCs requires cell-cell interactions. The molecular events leading to T-cell activation have been extensively investigated, but the underlying physical binding forces between T-cells and APCs are largely unknown. We used single cell force spectroscopy
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