FCMAB108A4

Anti-phospho-SMC1 (Ser957) Antibody, clone 5D11G5 Alexa Fluor^™ 488

clone 5D11G5, from mouse, ALEXA FLUOR^™ 488

• Synonyme(s) : CDLS2, DKFZp686L19178, DXS423E, KIAA0178, MGC138332, OTTHUMP00000061876, SB1.8, SMC1, SMC1A, SMC1L1, SMC1alpha, SMCB, Sb1.8, Smcb
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: mouse
• Niveau de qualité: 100
• Conjugué: ALEXA FLUOR^™ 488
• Forme d'anticorps: purified immunoglobulin
• Type de produit anticorps: primary antibodies
• Clone: 5D11G5, monoclonal
• Espèces réactives: human, Xenopus, bovine
• Technique(s): flow cytometry: suitable; western blot: suitable
• Isotype: IgG1
• Numéro d'accès NCBI: NM_006306
• Numéro d'accès UniProt: Q14683
• Conditions d'expédition: wet ice
• Modification post-traductionnelle de la cible: phosphorylation (pSer957)
• Informations sur le gène: human ... SMC1A(8243)

Description

Description générale

SMC (structural maintenance of chromosomes) proteins are Involved in chromosome cohesion during cell cycle and in DNA repair. ATM phosphorylates SMC1 on Ser957 and Ser966 both in vitro and in vivo. Phosphorylated SMC1 is part of the complex that functions as a downstream effector in both the ATM/NBS1 branch and the ATR/MSH2 branch of S-phase checkpoint.

Spécificité

Antibody recognizes SMC1 phosphorylolated at Ser957.

Predicted to cross-react with xenopus and bovine based on sequence homology

Immunogène

Epitope: Phosphorylated at and around Ser957

KLH-conjugated, synthetic peptide corresponding to human SMC1 phosphorylated at Ser957

Application

Research Category
Epigenetics & Nuclear Function

Apoptosis & Cancer

Research Sub Category
Cell Cycle, DNA Replication & Repair

This Anti-phospho-SMC1 (Ser957) Antibody, clone 5D11G5 Alexa Fluor 488 is validated for use in WB, FC for the detection of phospho-SMC1 (Ser957).

Qualité

Evaluated by Flow Cytometry with Hela Cells

Description de la cible

150kDa Calculated

Forme physique

Protein G Purified

Purified mouse monoclonal IgG1 conjugated to Alexa Flour 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA.

Stockage et stabilité

Maintain refrigerated at 2-8°C in undiluted aliquots for up to 6 months from date of receipt. Protect from light.

Remarque sur l'analyse

Control
HeLa Cells

Informations légales

ALEXA FLUOR is a trademark of Life Technologies

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable