ABS460

Anti-LEMD3 Antibody

from rabbit, purified by affinity chromatography

• Synonyme(s) : LEM domain containing 3, Inner nuclear membrane protein Man1
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Produit purifié par: affinity chromatography
• Espèces réactives: human
• Technique(s): immunohistochemistry: suitable; western blot: suitable
• Numéro d'accès UniProt: Q9Y2U8
• Conditions d'expédition: wet ice
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... LEMD3(23592)

Description

Description générale

LEM domain-containing protein 3 (LEMD3), also known as Inner nuclear membrane protein Man1 (MAN1), is an inner nuclear membrane protein that interacts with BMP and activin-TGF-beta receptor-activated Smads and antagonizes TGF-beta signaling in human cells. Additionally, LEMD3 is shown to Interact with SMAD1, SMAD2, SMAD3 and SMAD5. Studies also show that LEMD3 binds to both the phosphorylated and the unphosphorylated R-SMADS. LEMD3 is expressed in heart, brain, placenta, lung, liver and skeletal muscle. Defects in LEMD3 are shown to cause disorders, such as osteopoikilosis, Buschke-Ollendorff syndrome (BOS), and melorheostosis (MEL).

Immunogène

KLH-conjugated linear peptide corresponding to human LEMD3.

Application

Anti-LEMD3 Antibody is a highly specific rabbit polyclonal antibody, that targets LEM domain-containing protein 3 & has been tested in western blotting & IHC.

Immunohistochemistry Analysis: 2.5 µg/mL from a representative lot detected LEMD3 in human colon tissue.

Research Category
Signaling

Research Sub Category
Developmental Signaling

Qualité

Evaluated by Western Blotting in human colon tissue lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected LEMD3 in 15 µg of human colon tissue lysate.

Description de la cible

~120 kDa observed. Uncharacterized bands may appear in some lysate(s).

Forme physique

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Stockage et stabilité

Stable for 1 year at 2-8°C from date of receipt.

Remarque sur l'analyse

Control
Human colon tissue lysate

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable