ABC498
Anti-BCL2A1 Antibody/BFL-1
serum, from rabbit
Synonyme(s) :
Bcl-2-related protein A1, Bcl-2-like protein 5, Bcl2-L-5, Hemopoietic-specific early response protein, Protein BFL-1, Protein GRS
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About This Item
Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41
Source biologique
rabbit
Niveau de qualité
Forme d'anticorps
serum
Type de produit anticorps
primary antibodies
Clone
polyclonal
Espèces réactives
human
Technique(s)
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... BCL2A1(597)
Description générale
Bcl-2-related protein A1 (BCL2A1), also known as protein BFL-1, protein GRS, and Bcl-2-like protein 5 (Bcl2-L-5), is a member of the Bcl-2 family. BCL2A1/BFL-1 can interact with Bax and suppress apoptosis by inhibiting the release of cytochrome c and caspase-3 activation. BCL2A1/BFL-1 is expressed in peripheral blood, spleen, bone marrow, lung, small intestine, and testis.
Immunogène
Recombinant protein corresponding to human BCL2A1/BFL-1.
Application
Research Category
Apoptosis & Cancer
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
Apoptosis - Additional
This Anti-BCL2A1 Antibody/BFL-1 is validated for use in Western Blotting and Immunohistochemistry and Immunoprecipitation for the detection of BCL2A1/BFL-1.
Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected BCL2A1/BFL-1 in 0.2 µg of Jurkat cell lysate.
Western Blotting Analysis: A representative lot detected BCL2A1/BFL-1 in human lymphoma cell lysate (Yecies, D., et al. (2010). Blood. 115(16):3304-13).
Western Blotting Analysis: A representative lot detected BCL2A1/BFL-1 in chronic lymphocytic leukemia cell lysate (Natoni, A., et al. (2011). Mol Cancer Ther. 10(9):1624-1634).
Immunohistochemistry Analysis: A representative lot detected BCL2A1/BFL-1 in lymph node tissue (Vogler, M., et al. (2009). Blood. 113(18): 4403-4413).
Immunoprecipitation Analysis: A representative lot immunoprecipitated BCL2A1/BFL-1 in chronic lymphocytic leukemia cell lysate (Vogler, M., et al. (2009). Blood. 113(18): 4403-4413).
Western Blotting Analysis: A representative lot detected BCL2A1/BFL-1 in human lymphoma cell lysate (Yecies, D., et al. (2010). Blood. 115(16):3304-13).
Western Blotting Analysis: A representative lot detected BCL2A1/BFL-1 in chronic lymphocytic leukemia cell lysate (Natoni, A., et al. (2011). Mol Cancer Ther. 10(9):1624-1634).
Immunohistochemistry Analysis: A representative lot detected BCL2A1/BFL-1 in lymph node tissue (Vogler, M., et al. (2009). Blood. 113(18): 4403-4413).
Immunoprecipitation Analysis: A representative lot immunoprecipitated BCL2A1/BFL-1 in chronic lymphocytic leukemia cell lysate (Vogler, M., et al. (2009). Blood. 113(18): 4403-4413).
Qualité
Evaluated by Western Blotting in human BFL-1 recombinant protein.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected BCL2A1/BFL-1 in 0.2 µg of human BFL-1 recombinant protein.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected BCL2A1/BFL-1 in 0.2 µg of human BFL-1 recombinant protein.
Description de la cible
~20 kDa observed. Uncharacterized band(s) may appear in some lysates.
Forme physique
Rabbit polyclonal serum with 0.05% sodium azide.
Unpurified
Stockage et stabilité
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Mechanisms of action of a dual Cdc7/Cdk9 kinase inhibitor against quiescent and proliferating CLL cells.
Natoni, Alessandro, et al.
Molecular Cancer Therapeutics, 10, 1624-1634 (2011)
Meike Vogler et al.
Blood, 113(18), 4403-4413 (2008-11-15)
ABT-737 and its orally active analog, ABT-263, are rationally designed inhibitors of BCL2 and BCL-X(L). ABT-263 shows promising activity in early phase 1 clinical trials in B-cell malignancies, particularly chronic lymphocytic leukemia (CLL). In vitro, peripheral blood CLL cells are
Derek Yecies et al.
Blood, 115(16), 3304-3313 (2010-03-04)
ABT-737 is a small-molecule antagonist of BCL-2 currently under evaluation in clinical trials in the oral form of ABT-263. We anticipate that acquired resistance to this promising drug will inevitably arise. To study potential mechanisms of resistance to ABT-737, we
Anie P Masilamani et al.
Cancers, 12(6) (2020-06-26)
Background: Upregulation of anti-apoptotic Bcl-2 proteins in advanced prostate cancer leads to therapeutic resistance by prevention of cell death. New therapeutic approaches aim to target the Bcl-2 proteins for the restoration of apoptosis. Methods: The immunotoxin hD7-1(VL-VH)-PE40 specifically binds to
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