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Principaux documents

AB5888

Sigma-Aldrich

Anti-NOGO A Antibody

Chemicon®, from rabbit

Synonyme(s) :

Neurite outgrowth inihibitor A

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Produit purifié par

affinity chromatography

Espèces réactives

mouse, human, rat

Fabricant/nom de marque

Chemicon®

Technique(s)

western blot: suitable

Numéro d'accès NCBI

NP_077188.1

Numéro d'accès UniProt

Q99P72

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

mouse ... Rtn4(68585)

Description générale

This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified

Spécificité

Cat. # AB5888 is specific to NOGO A. It does not recognize NOGO B or NOGO C.
Reactivity with other species has not been tested.

Application

Anti-NOGO A Antibody detects level of NOGO A & has been published & validated for use in WB.

Qualité

Routinely tested on mouse brain lysate

Description de la cible

Theoretical MW is approx. 126 kDa however literature reports observed molecular weight to be 205 kDa to 220 kDa

Informations légales

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Feng Tan et al.
Experimental and therapeutic medicine, 16(6), 4943-4950 (2018-12-14)
Electroacupuncture (EA) may stimulate neurogenesis in animal models of ischemic stroke; however, the associated mechanisms are not clear. The present study aimed to evaluate the neurogenesis efficacy of EA on ischemic stroke and the underlying associated mechanisms. A model of
Soluble Nogo-A, an inhibitor of axonal regeneration, as a biomarker for multiple sclerosis.
Anna Jurewicz,Mariola Matysiak,Cedric S Raine,Krzysztof Selmaj
Neurology null
Giuseppe Vaccaro et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 42(20), 4087-4100 (2022-04-20)
Nogo-66 receptors (NgR1-3) are glycosylphosphatidyl inositol-linked proteins that belong to the leucine-rich repeat superfamily. Through binding to myelin-associated inhibitors, NgRs contribute to the inhibition of axonal regeneration after spinal cord injury. Their role in limiting synaptic plasticity and axonal outgrowth
Ryan L O'Hare Doig et al.
BMC neuroscience, 18(1), 62-62 (2017-08-16)
Following partial injury to the central nervous system, cells beyond the initial injury site undergo secondary degeneration, exacerbating loss of neurons, compact myelin and function. Changes in Ca2+ flux are associated with metabolic and structural changes, but it is not
Jae Young Lee et al.
Scientific reports, 7(1), 8958-8958 (2017-08-23)
Axo-glial units are highly organised microstructures propagating saltatory conduction and are disrupted during multiple sclerosis (MS). Nogo receptor 1 (NgR1) has been suggested to govern axonal damage during the progression of disease in the MS-like mouse model, experimental autoimmune encephalomyelitis
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