654164

Tubulin Polymerization Inhibitor II

The Tubulin Polymerization Inhibitor II, also referenced under CAS 1151995-69-5, acts as an effective anti-microtubule agent. This small molecule/inhibitor is primarily used for Cell Structure applications.

• Synonyme(s) : Tubulin Polymerization Inhibitor II, (E)-1,3-Dihydro-6-methoxy-3-(3,4,5-trimethoxybenzylidene)-1H-indol-2-one
• Formule empirique (notation de Hill) : C₁₉H₁₉NO₅
• Numéro CAS: 1151995-69-5
• Poids moléculaire : 341.36
• Numéro MDL: MFCD28138101
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥97% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: yellow
• Solubilité: DMSO: 10 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• Chaîne SMILES: N1c2c(ccc(c2)OC)C(=Cc3cc(c(c(c3)OC)OC)OC)C1=O
• InChI: 1S/C19H19NO5/c1-22-12-5-6-13-14(19(21)20-15(13)10-12)7-11-8-16(23-2)18(25-4)17(9-11)24-3/h5-10H,1-4H3,(H,20,21)
• Clé InChI: YLUHXAHNPQALMQ-UHFFFAOYSA-N

Description

Description générale

A cell-permeable, SU5416- (Cat. Nos. 676487 and 676498) derived combretastatin A-4 (Cat. No. 234200) analog that acts as an effective anti-microtubule agent (IC₅₀ = 4.5 µM in inhibiting polymerization of purified porcine brain tubulin) and displays extremely potent anti-proliferative activity towards various cancer cell lines (GI₅₀<10 nM for 46 lines among a 53 NCI panel tested).

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
Purified porcine brain tubulin

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 4.5 µM in inhibiting polymerization of purified porcine brain tubulin

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Harmful (C)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Pandit, B., et al. 2006. Bioorg. Med. Chem.14, 6492.
Li, P.K., et al. 2005. Bioorg. Med. Chem. Lett.15, 5382.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable