565763

γ-Secretase Inhibitor VI

The γ-Secretase Inhibitor VI, also referenced under CAS 287196-57-0, controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

• Synonyme(s) : γ-Secretase Inhibitor VI, 1-(S)- endo-N-(1,3,3)-Trimethylbicyclo[2.2.1]hept-2-yl)-4-fluorophenyl Sulfonamide, 1-(S)-endo-N-(1,3,3)-Trimethylbicyclo[2.2.1]hept-2-yl)-4-fluorophenyl Sulfonamide
• Formule empirique (notation de Hill) : C₁₆H₂₂FNO₂S
• Numéro CAS: 287196-57-0
• Poids moléculaire : 311.41
• Numéro MDL: MFCD03453572
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.54

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Couleur: white
• Solubilité: DMSO: 200 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: −20°C

Description

Description générale

A potent, cell-permeable inhibitor of γ-secretase that blocks the formation of Aβ₄₂ (IC₅₀ = 1.8 µM). Treatment of HEK293 cells with γ-secretase inhibitor VI results in an increase in β-secretase-cleaved, APP fragments and secreted APP_Sα, but no change in secreted APP_Sβ, indicating a specific inhibition of γ-secretase activity.

Cell permeable. Potently inhibits Aβ₄₂ production (IC₅₀ = 1.8 µM). Treatment of HEK293 cells with this inhibitor results in β-Secretase-cleaved APP fragments and secreted APPα, but no change in secreted APPsβ is observed indicating specific inhibition of γ-secretase.

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
Aβ₄₂ production

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 1.8 µM against Aβ42 production

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze at (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Autres remarques

Rishton, G.M., et al. 2000. J. Med. Chem.43, 2297.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable