496915

Oridonin, R. rubescens

A cell-permeable diterpenoid compound that possesses anti NF-κB activity and displays antiproliferative and antiangiogenic properties.

• Synonyme(s) : Oridonin, R. rubescens
• Formule empirique (notation de Hill) : C₂₀H₂₈O₆
• Numéro CAS: 28957-04-2
• Poids moléculaire : 364.43
• Numéro MDL: MFCD00221762
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Description: RTECS - NZ8177000
• Essai: ≥93% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: yellow
• Solubilité: DMSO: 10 mg/mL
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Chaîne SMILES: O1[C@]2([C@]43[C@H]([C@]5([C@H]([C@@H]2O)C(CC[C@@H]5O)(C)C)C1)CC[C@H]([C@H]4O)C(=C)C3=O)O
• InChI: 1S/C20H28O6/c1-9-10-4-5-11-18-8-26-20(25,19(11,14(9)22)15(10)23)16(24)13(18)17(2,3)7-6-12(18)21/h10-13,15-16,21,23-25H,1,4-8H2,2-3H3/t10-,11-,12-,13+,15+,16-,18+,19-,20+/m0/s1
• Clé InChI: SDHTXBWLVGWJFT-XKCURVIJSA-N

Description

Description générale

A cell-permeable diterpenoid compound that possesses anti NF-κB activity and displays antiproliferative (ED₅₀ = ~ 2.7 µg/ml in lymphoid malignant cells) and antiangiogenic properties (significantly inhibits network formation of HMEC-1 cells at 2.5 µg/ml). Reported to affect DNA synthesis, induce apoptosis and initiate cell cycle arrest. Shown to efficiently block both TNF-α and LPS-induced NF-κB activity in Jurkat and in RAW264.7 murine macrophages, and inhibit p65 NF-κB transcriptional activity (IC₅₀ = ~ 5 µg/ml in MT-1 cells) by disrupting NF-κB DNA-binding activity without interfering with its nuclear translocation.

A cell-permeable inhibitor of NF-κB activity that displays antiproliferative (ED₅₀ ~ 2.7 µg/ml in lymphoid malignant cells) and antiangiogenic properties (significantly inhibits network formation of HMEC-1 cells at 2.5 µg/ml). Reported to affect DNA synthesis, induce apoptosis, and initiate cell cycle arrest. Shown to efficiently block both TNF-α and LPS-induced NF-κB activity in Jurkat and in RAW264.7 murine macrophages. Also inhibits p65 NF-κB transcriptional activity (IC₅₀ ~5 µg/ml in MT-1 cells) by disrupting NF-κB DNA-binding activity without interfering with its nuclear translocation.

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
NF-κB transcriptional activity

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 5 µg/ml inhibiting p65 NF-κB transcriptional activity in MT-1 cells

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Use only fresh DMSO for reconstitution.

Autres remarques

Ikezoe, T., et al. 2005. Mol. Cancer Ther.4, 578.
Meade-Tollin, L.C., et al. 2004. J. Nat. Prod.67, 2.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable