492905

Nucleozin

A cell-permeable isoxazolylpiperazine compound that is shown to inhibit influenza A H1N1 (A/WSN/33 strain), H3N2 (clinical isolate), and H5N1 (A/Vietnam/1194/04) replication in MDCK cells.

• Synonyme(s) : Nucleozin
• Formule empirique (notation de Hill) : C₂₁H₁₉ClN₄O₄
• Numéro CAS: 341001-38-5
• Poids moléculaire : 426.85
• Numéro MDL: MFCD01426660
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.51

Propriétés

• Niveau de qualité: 100
• Essai: ≥95% (HPLC)
• Forme: powder
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Couleur: yellow
• Solubilité: DMSO: 20 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• Chaîne SMILES: Clc1c(ccc(c1)[N+](=O)[O-])N2CCN(CC2)C(=O)c3c(n[o]c3C)c4ccccc4
• InChI: 1S/C21H19ClN4O4/c1-14-19(20(23-30-14)15-5-3-2-4-6-15)21(27)25-11-9-24(10-12-25)18-8-7-16(26(28)29)13-17(18)22/h2-8,13H,9-12H2,1H3
• Clé InChI: OWXBJAPOSQSWAO-UHFFFAOYSA-N

Description

Description générale

A cell-permeable isoxazolylpiperazine compound that is shown to inhibit influenza A H1N1 (A/WSN/33 strain), H3N2 (clinical isolate), and H5N1 (A/Vietnam/1194/04) replication in MDCK cells in vitro (EC₅₀ = 69, 160, and 330 nM, respectively) and significantly reduce fatality after A/Vietnam/1194/04 infection in mice in vivo (50% survial rate on day 21 with 14 b.i.d. i.p. doses of 230 µg/mouse in the first 7 days after infection) by preventing nucleoprotein (NP) nuclear accumulation via NP aggregation induction during early stages of viral infection. Virus strains with N309K or Y289H NP mutation, such as swine-origin influenza A (S-OIV) H1N1, are found to be resistant to Nucleozin, consistent with the N309-mediated hydrogen bonding and Y289-mediated hydrophobic interaction with Nucleozin as predicted by computer-aided docking studies.

Avertissement

Toxicity: Standard Handling (A)

Autres remarques

Kao, R.Y., et al. 2010. Nat. Biotechnol.28, 600.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable