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870601C

Avanti

Azelaoyl-PAF

Avanti Research™ - A Croda Brand 870601C

Synonyme(s) :

1-hexadecyl-2-azelaoyl-sn-glycero-3-phosphocholine

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About This Item

Formule empirique (notation de Hill) :
C33H66NO9P
Numéro CAS:
354583-69-0
Poids moléculaire :
651.85
Numéro MDL:
MFCD03412018
Code UNSPSC :
12352211
Nomenclature NACRES :
NA.25

Forme

liquid

Conditionnement

pkg of 1 × 1 mL (870601C-1mg)

Fabricant/nom de marque

Avanti Research™ - A Croda Brand 870601C

Concentration

1 mg/mL (870601C-1mg)

Conditions d'expédition

dry ice

Température de stockage

−20°C

Chaîne SMILES 

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCC(O)=O)=O)COCCCCCCCCCCCCCCCC)=O

InChI

1S/C33H66NO9P/c1-5-6-7-8-9-10-11-12-13-14-15-16-20-23-27-40-29-31(30-42-44(38,39)41-28-26-34(2,3)4)43-33(37)25-22-19-17-18-21-24-32(35)36/h31H,5-30H2,1-4H3,(H-,35,36,38,39)/t31-/m1/s1

Clé InChI

ZDFOCDTXDPKJKA-WJOKGBTCSA-N

Description générale

1-hexadecyl-2-azelaoyl-sn-glycero-3-phosphocholine (Azelaoyl-PAF) Azelaoyl-PAF is an alkyl phosphatidylcholine and is a component of the lipid pool within oxidized low-density lipoprotein (oxLDL) particles. Azelaoyl-PAF is a low molecular weight phospholipid.

Application

Azelaoyl-PAF may be used in binding assay of anti-inflammatory peptides, 2F and 4F.

Actions biochimiques/physiologiques

1-hexadecyl-2-azelaoyl-sn-glycero-3-phosphocholine (Azelaoyl-PAF) acts as an agonist for peroxisome proliferator-activated receptors γ(PPAR-γ). It may be used as a therapeutic for Friedreich′s ataxia (FRDA). At low concentrations azelaoyl-PAF may induce apoptosis.

Conditionnement

5 mL Clear Glass Sealed Ampule (870601C-1mg)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictogrammes

Skull and crossbonesHealth hazard
GHS06,GHS08

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Organes cibles

Central nervous system, Liver,Kidney

Classe de danger pour l'eau (WGK)

WGK 3

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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

PPAR-gamma agonist azelaoyl PAF increases frataxin protein and mRNA expression. New implications for the friedreich?s ataxia therapy
Marmolino D, et al.
Cerebellum, 8(2), 98-103 (2009)
Anti-inflammatory peptides grab on to the whiskers of atherogenic oxidized lipids
Epand RF, et al.
Biochimica et Biophysica Acta - Biomembranes, 1788(9), 1967-1975 (2009)
S S Davies et al.
The Journal of biological chemistry, 276(19), 16015-16023 (2001-03-30)
Synthetic high affinity peroxisome proliferator-activated receptor (PPAR) agonists are known, but biologic ligands are of low affinity. Oxidized low density lipoprotein (oxLDL) is inflammatory and signals through PPARs. We showed, by phospholipase A(1) digestion, that PPARgamma agonists in oxLDL arise
P Tontonoz et al.
Cell, 93(2), 241-252 (1998-05-06)
The formation of foam cells from macrophages in the arterial wall is characterized by dramatic changes in lipid metabolism, including increased expression of scavenger receptors and the uptake of oxidized low-density lipoprotein (oxLDL). We demonstrate here that the nuclear receptor
Douglas S Watson et al.
Vaccine, 27(34), 4672-4683 (2009-06-13)
The membrane proximal region (MPR) of HIV-1 gp41 is a desirable target for development of a vaccine that elicits neutralizing antibodies since the patient-derived monoclonal antibodies, 2F5 and 4E10, bind to the MPR and neutralize primary HIV isolates. The 2F5

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