929476

N-Acetyl-S-(2-amino-9-(4-fluorobenzyl)-6-oxo-6,9-dihydro-1H-purin-8-yl)-L-cysteine

≥95%

• Synonyme(s) : p-Fluorobenzylguanine ligand, AUTAC ligand, FBnG
• Formule empirique (notation de Hill) : C₁₇H₁₇FN₆O₄S
• Numéro CAS: 2241669-86-1
• Poids moléculaire : 420.42
• Numéro MDL: MFCD32670504
• Code UNSPSC : 12352209
• Nomenclature NACRES : NA.21

Propriétés

• Niveau de qualité: 100
• Essai: ≥95%
• Forme: powder or chunks
• Pertinence de la réaction: reagent type: ligand
• Température de stockage: 2-8°C
• Chaîne SMILES: O=C1NC(N)=NC2=C1N=C(SC[C@@H](C(O)=O)NC(C)=O)N2CC3=CC=C(C=C3)F

Description

Application

N-acetyl-S-(2-amino-9-(4-fluorobenzyl)-6-oxo-6,9-dihydro-1H-purin-8-yl)-L-cysteine is a p-fluorobenzylguanine (FBnG) based ligand used to initiate selective autophagy as a strategy for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology.

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Autres remarques

AUTACs: Cargo-Specific Degraders Using Selective Autophagy

Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel-Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7

BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design

Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs

Systematic exploration of different E3 ubiquitin ligases: an approach towards potent and selective CDK6 degraders

Informations légales

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable