SML3989

DRP1 Inhibitor, MIDI

≥98% (HPLC)

• Synonym(s): 1,1′-(1,4-Phenylene)bis[3-(3-pyridinyl)-2-propen-1-one], MIDI
• Empirical Formula (Hill Notation): C₂₂H₁₆N₂O₂
• CAS Number: 348145-43-7
• Molecular Weight: 340.37
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 0.5 mg/mL, clear (Warmed)
• storage temp.: room temp
• SMILES string: O=C(/C=C/C1=CC=CN=C1)C2=CC=C(C(/C=C/C3=CC=CN=C3)=O)C=C2
• InChI key: IOESTAVFGVAMRH-YDWXAUTNSA-N

Description

Biochem/physiol Actions

Mitochondrial fission inhibitor that blocks DRP1 recruitment to mitochondria.



DRP1 Inhibitor MIDI is a cell-permeable, symmetrical pyridinyl-propenone compound that acts as a potent, time-dependent mitochondrial fission inhibitor (0.5 - 2 µM) and functionally mimics DRP1 knockout. MIDI is shown to covalently interact with DRP1-C367 and disrupt DRP1 interaction with its mitochondrial receptors MFF and MiD49/51. Blocks stress-induced mitochondrial fragmentation and promotes mitochondrial hyperfusion. MIDI does neither obstruct DRP1 tetramerization nor its GTPase activity. Poorly affects mitochondrial oxygen consumption rate and glycolysis activity.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable