SBR00096

Lefamulin

≥98% (HPLC), powder

• Synonym(s): BC-3781
• Empirical Formula (Hill Notation): C₂₈H₄₅NO₅S
• CAS Number: 1061337-51-6
• Molecular Weight: 507.73
• UNSPSC Code: 51101500

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• antibiotic activity spectrum: Gram-negative bacteria; Gram-positive bacteria
• Mode of action: protein synthesis | inhibits
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: CC1CCC23CCC(=O)C2C1(C(CC(C(C3C)O)(C)C=C)OC(=O)CSC4CCC(CC4O)N)C
• InChI: 1S/C28H45NO5S/c1-6-26(4)14-22(34-23(32)15-35-21-8-7-18(29)13-20(21)31)27(5)16(2)9-11-28(17(3)25(26)33)12-10-19(30)24(27)28/h6,16-18,20-22,24-25,31,33H,1,7-15,29H2,2-5H3/t16-,17+,18-,20-,21-,22-,24+,25+,26-,27+,28+/m1/s1
• InChI key: KPVIXBKIJXZQJX-FCEONZPQSA-N

Description

General description

Lefamulin is an antibiotic which belongs to a class of coumpounds known as pleuromutilins. It is a semisynthetic derivative of the naturally occurring antibiotic pleuromutilin, and it is used for the treatment of bacterial infections.

Biochem/physiol Actions

Lefamulin inhibits bacterial protein synthesis by binding to the 50S subunit of the bacterial ribosome. Specifically, it binds to the peptidyl transferase center of the ribosome and inhibits the transfer of amino acids to growing polypeptide chains, which leads to the inhibition of bacterial protein synthesis and bacterial death. Lefamulin is active against a wide range of Gram-positive bacteria, including Streptococcus pneumoniae, Staphylococcus aureus, and methicillin-resistant S. aureus (MRSA), as well as some atypical bacteria such as Legionella species. It has also been shown to have activity against some Gram-negative bacteria, including Haemophilus influenzae and Moraxella catarrhalis.

Safety Information

• Pictograms: GHS08
• Signal Word: Warning
• Hazard Statements: H371
• Precautionary Statements: P260 - P264 - P270 - P308 + P311 - P405 - P501
• Hazard Classifications: STOT SE 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable