SML3014

KL101

≥98% (HPLC)

• Synonym(s): N-(2-(2,4-Dimethylphenyl)-2,6-dihydro-4H-thieno[3,4-c]pyrazol-3-yl)-3,4-dimethyl-benzamide
• Empirical Formula (Hill Notation): C₂₂H₂₃N₃OS
• CAS Number: 396721-89-4
• Molecular Weight: 377.50
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: CC1=CC=C(C(NC2=C(CSC3)C3=NN2C4=C(C)C=C(C)C=C4)=O)C=C1C
• InChI: 1S/C22H23N3OS/c1-13-5-8-20(16(4)9-13)25-21(18-11-27-12-19(18)24-25)23-22(26)17-7-6-14(2)15(3)10-17/h5-10H,11-12H2,1-4H3,(H,23,26)
• InChI key: FJKKXWLUKJOWNU-UHFFFAOYSA-N

Description

Biochem/physiol Actions

KL101 is a circadian clock modulator that lengthens a circadian period in cells and tissues. It selectively stabilizes CRY1 through interaction with FAD-binding pocket. KL101 strongly enhanced brown adipocyte differentiation in culture. KL101 showed no or only minor effects on CKIδ, CKIα and CK2 activities in vitro.

circadian clock modulator that selectively stabilizes CRY1

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable