AB1929
Anti-Integrin β1 Antibody, phospho-specific [Thr788/Thr789]
Chemicon®, from rabbit
Synonym(s):
CD29, Integrin VLA-4 subunit beta, Fibronectin receptor subunit beta
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
phosphorylation (pThr788/pThr789)
Gene Information
human ... ITGB1(3688)
General description
Integrin beta1 is a transmembrane glycoprotein that forms noncovalent complexes with various alpha integrin subunits to form the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metatastatic diffusion of tumor cells. Interactions between integrins and extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression. Phosphorylation of threonines 788 and 789 on integrin beta1 receptor may play a key role in cell-cycle dependent regulation.
Specificity
The antibody detects a 130 kDa protein of integrin beta1 receptor.
Immunogen
Epitope: pT788/789
Phosphorylated synthetic peptide corresponding to amino acid residues surrounding and including threonine 788/789 of the human beta1 integrin. The immunogen sequence is 100% identical in mouse, rat and chicken integrin beta1.
Application
Anti-Integrin β1 Antibody, phospho-specific [Thr788/Thr789] is an antibody against Integrin β1 for use in WB.
Research Category
Cell Structure
Cell Structure
Research Sub Category
Integrins
Integrins
Western Blot: 1:1000.
Optimal working dilutions must be determined by end user.
Optimal working dilutions must be determined by end user.
Linkage
Replaces: 04-1109
Physical form
Antibody is cross-adsorbed to nonphospho-peptide corresponding to the site of phosphorylation then affinity purified using phosphorylated integrin beta1 receptor (Thr788/789) peptide. Antibody is supplied in Dulbecco′s phosphate-buffered saline (without Mg2+ or Ca2+), pH 7.3, 50% glycerol and 1 mg/mL BSA.
ImmunoAffinity Purified
Storage and Stability
Maintain at -20°C for up to one year from date of receipt. Avoid repeated freeze/thaw cycles.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Not finding the right product?
Try our Product Selector Tool.
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
A Richardson et al.
BioEssays : news and reviews in molecular, cellular and developmental biology, 17(3), 229-236 (1995-03-01)
The integrins are receptors for proteins of the extracellular matrix, both providing a physical link to the cytoskeleton and transducing signals from the extracellular matrix. Activation of integrins leads to tyrosine and serine phosphorylation of a number of proteins, elevation
B P Liu et al.
Molecular and cellular biology, 20(19), 7160-7169 (2000-09-13)
The Rho family of GTPases plays a major role in the organization of the actin cytoskeleton. These G proteins are activated by guanine nucleotide exchange factors that stimulate the exchange of bound GDP for GTP. In their GTP-bound state, these
W T Arthur et al.
Current biology : CB, 10(12), 719-722 (2000-06-30)
The Rho family GTPases Cdc42, Rac1 and RhoA control many of the changes in the actin cytoskeleton that are triggered when growth factor receptors and integrins bind their ligands [1] [2]. Rac1 and Cdc42 stimulate the formation of protrusive structures
S D Blystone et al.
The Journal of cell biology, 145(4), 889-897 (1999-05-20)
Many cells express more than one integrin receptor for extracellular matrix, and in vivo these receptors may be simultaneously engaged. Ligation of one integrin may influence the behavior of others on the cell, a phenomenon we have called integrin crosstalk.
A Anselmo et al.
Cell death and differentiation, 23(8), 1322-1330 (2016-03-19)
Establishment of cell-cell adhesion is crucial in embryonic development as well as within the stem cell niches of an adult. Adhesion between macrophages and erythroblasts is required for the formation of erythroblastic islands, specialized niches where erythroblasts proliferate and differentiate
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service