SML3308
RyR1-selective inhibitor 1
≥98% (HPLC)
Synonym(s):
5,8-Dihydro-5-octyl-8-oxo-1,3-dioxolo[4,5-g]quinoline-7-carboxylic acid sodium salt
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About This Item
Empirical Formula (Hill Notation):
C19H22NO5·Na
Molecular Weight:
367.37
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 2 mg/mL, clear (Warmed)
storage temp.
room temp
Biochem/physiol Actions
Potent and selective inhibitor of the type 1 ryanodine receptor (RyR1)
RyR1-selective inhibitor 1 (6,7-(methylenedioxy)-1-octyl-4-quinolone-3-carboxylic acid) potently and selectively inhibits the type 1 ryanodine receptor (RyR1). It prevents and treats malignant hyperthermia and heat stroke in several mouse models. RyR1-selective inhibitor 1 decreases resting intracellular Ca2+, inhibits halothane- and isoflurane-induced Ca2+ release, and suppresses caffeine-induced contracture in skeletal muscle.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Toshiko Yamazawa et al.
Nature communications, 12(1), 4293-4293 (2021-07-15)
Mutations in the type 1 ryanodine receptor (RyR1), a Ca2+ release channel in skeletal muscle, hyperactivate the channel to cause malignant hyperthermia (MH) and are implicated in severe heat stroke. Dantrolene, the only approved drug for MH, has the disadvantages
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