SML3118

Obatoclax mesylate

≥98% (HPLC)

• Synonym(s): 2-(2-((3,5-Dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl)-1H-indole, methanesulfonate salt, GX15-070 mesylate
• Empirical Formula (Hill Notation): C₂₀H₁₉N₃O · CH₄O₃S
• CAS Number: 803712-79-0
• Molecular Weight: 413.49
• MDL number: MFCD18074508
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: dark green to black
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: O=S(O)(C)=O.CC1=C(NC(C)=C1)/C=C2N=C(C3=CC4=C(N3)C=CC=C4)C=C\2OC
• InChI: 1S/C20H19N3O.CH4O3S/c1-12-8-13(2)21-16(12)10-19-20(24-3)11-18(23-19)17-9-14-6-4-5-7-15(14)22-17;1-5(2,3)4/h4-11,21-22H,1-3H3;1H3,(H,2,3,4)/b19-10-;
• InChI key: ZFKXDVMHNXPEIY-PEZBNFGJSA-N

Description

Biochem/physiol Actions

BH3 domain-targeting inhibitor against Bcl-2 family anti-apoptotic proteins with anti-cancer efficacy in vitro and in vivo.

Obatoclax (GX15–070) is a BH3 domain-targeting inhibitor against Bcl-2 family anti-apoptotic proteins, including A1/Bfl-1, Bcl-2, Bcl-B, Bcl-w, Bcl-XL, and MCL-1. Obatoclax induces cancer cell apoptosis in cultures (0.05-2 μM) and in vivo (1.25-10 mg/kg via im. ip. or iv. in mice) by overcoming Bcl-2 members-mediated resistance to BAX- or BAK-dependent apoptosis.

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H301,H315
• pcodes: P264 - P270 - P280 - P301 + P310 - P302 + P352 - P332 + P313
• Hazard Classifications: Acute Tox. 3 Oral - Skin Irrit. 2
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable