SBR00081

Favipiravir

≥97% (HPLC), powder

• Synonym(s): Favilavir, T-705
• Empirical Formula (Hill Notation): C₅H₄FN₃O₂
• CAS Number: 259793-96-9
• Molecular Weight: 157.10
• UNSPSC Code: 51101500

Properties

• Quality Level: 100
• assay: ≥97% (HPLC)
• form: powder
• color: white to yellow
• antibiotic activity spectrum: viruses
• mode of action: enzyme | inhibits
• storage temp.: −20°C
• SMILES string: C1=C(N=C(C(=O)N1)C(=O)N)F
• InChI: InChI=1S/C5H4FN3O2/c6-2-1-8-5(11)3(9-2)4(7)10/h1H,(H2,7,10)(H,8,11)
• InChI key: ZCGNOVWYSGBHAU-UHFFFAOYSA-N

Description

General description

Favipiravir is a pyrazinecarboxamide derivative which is an RNA polymerase inhibitors. Favipiravir is converted to the ribofuranosyltriphosphate derivative by host enzymes and selectively inhibits the influenza viral RNA-dependent RNA polymerase. Favipiravir has broad-spectrum activity against RNA viruses, including influenza viruses, arena viruses, bunyaviruses, and flaviviruses.

Biochem/physiol Actions

Favipiravir inhibits the RNA-dependent RNA polymerase enzyme, which is essential for the replication of RNA viruses such as influenza and SARS-CoV-2 (the virus that causes COVID-19). Inhibition of RNA-dependent RNA polymerase activity leads to the disruption of viral RNA replication and ultimately, the reduction of viral load.

Safety Information

• pictograms: GHS08
• signalword: Warning
• hcodes: H341,H361d
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Muta. 2 - Repr. 2
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable