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SBR00067

Sigma-Aldrich

Rifampicin Water Soluble

solubility: 50 mg/mL in water, freely soluble

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About This Item

UNSPSC Code:
51283601
NACRES:
NA.76
Pricing and availability is not currently available.

form

solid

Quality Level

200

specific activity

(Antibacterial)

solubility

water: freely soluble 50 mg/mL

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria
mycobacteria
viruses

mode of action

protein synthesis | interferes

storage temp.

−20°C

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Bis(4-hydroxyphenyl)methane 98%

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(S)-H8-BINAP technical grade

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Hexachlorophene ≥95% (HPLC)

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Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

mp

113-118 °C (lit.)

mp

162-164 °C (lit.)

mp

-

mp

-

form

powder

form

crystals

form

powder

form

powder

General description

Rifampicin is used to treat Tuberculosis and Tuberculosis-related mycobacterial infections.[1] Rifampicin is widely used as an antipruritic agent in the autoimmune cholestatic liver disease, and primary biliary cirrhosis (PBC).[2] Rifampicin was also found active by inhibiting Tau Oligomer Propagation in Alzheimer’s disease.[3] In addition, Rifampicin is used as a selection agent for agrobacterium mediated plant transformation.[4]

Application

Rifampicin is used to treat Tuberculosis and Tuberculosis-related mycobacterial infections. It is widely used as an antipruritic agent in the autoimmune cholestatic liver disease, primary biliary cirrhosis (PBC). It has been shown to cause hepatitis.

Biochem/physiol Actions

Rifampicin inhibits the assembly of DNA and protein into mature virus particles. It inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase, which results in cell death.

Mode of Action: Inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase. Inhibits the assembly of DNA and protein into mature virus particles.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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    Specific packaging of custom RNA molecules into cowpea mosaic virus-like particles.
    Peyret, Hadrien, et al
    Recombinant proteins from plants: production and isolation of clinically useful compounds, 103-111 (2022)
    Treatment of rifampicin-resistant tuberculosis disease and infection in children: key updates, challenges and opportunities
    Howell, Pauline, et al.
    Pathogens (Basel, Switzerland), 11.4, 381-381 (2022)

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