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Key Documents

SAB4700755

Sigma-Aldrich

Monoclonal Anti-CD82 antibody produced in mouse

clone C33, purified immunoglobulin, buffered aqueous solution

Synonym(s):

4F9, C33, IA4, R2, Anti-KAI1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

C33, monoclonal

form

buffered aqueous solution

species reactivity

human

concentration

1 mg/mL

technique(s)

FUNC: suitable
flow cytometry: suitable
immunoblotting: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable

isotype

IgG2a

NCBI accession no.

NM_001024844.1

UniProt accession no.

P27701

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... CD82(3732)

General description

The cluster of differentiation 82 (CD82)/Kangai 1 (KAI1), a type III transmembrane protein, is a member of the tetraspanin superfamily. It has four putative transmembrane domains and one small and one large extracellular loop. CD82 is widely expressed in normal tissues. Its mRNA is seen at high levels in the spleen, placenta, lung, liver, kidney, and prostate. CD82 was previously identified as lymphocyte cell-surface protein. The KAI1/CD82 gene is mapped to human chromosome 11p11.2.

Immunogen

C91/PL (human HTLV-1+ T cell line)

Biochem/physiol Actions

The cluster of differentiation 82 (CD82)/Kangai 1 (KAI1) protein is a metastasis suppressor. It inhibits the migration and invasion of cancer cells. CD82 plays a key role in cell adhesion, fusion, apoptosis, and morphogenesis. CD82 can mobilize intracellular Ca2+ in lymphocytes. It acts as an accessory molecule in the activation of the T-cell. CD82 has an inhibitory role in syncytium formation caused by the human T-cell leukemia virus in immune cells (HTLV). Lower expression of CD82 is observed in several cancers, including prostate and lung cancer.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
512728

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Hélène Tonoli et al.
Trends in molecular medicine, 11(12), 563-570 (2005-11-08)
The transmembrane glycoprotein CD82 is a member of the tetraspanin protein family and is a metastasis suppressor implicated in biological processes ranging from fusion, adhesion and migration to apoptosis and cell-morphology alterations. Downregulation of CD82 expression is associated with the
Wei M Liu et al.
Cancer letters, 240(2), 183-194 (2005-11-02)
Tetraspanin KAI1/CD82 is a wide-spectrum tumor metastasis suppressor. KAI1/CD82 suppresses tumor metastasis by primarily inhibiting cancer cell motility and invasiveness. In tetraspanin-enriched microdomain, KAI1/CD82 associates with the proteins important for cell migration such as cell adhesion molecule, growth factor receptor
Ulrike Klenke et al.
Endocrinology, 155(5), 1851-1863 (2014-02-26)
Metabolic dysfunctions are often linked to reproductive abnormalities. Adiponectin (ADP), a peripheral hormone secreted by white adipose tissue, is important in energy homeostasis and appetite regulation. GnRH neurons are integral components of the reproductive axis, controlling synthesis, and release of

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