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Key Documents

SAB4300254

Sigma-Aldrich

Anti-phospho-NTRK1 (pSer791) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-DKFZp781I14186 antibody produced in rabbit, Anti-MTC antibody produced in rabbit, Anti-TRK antibody produced in rabbit, Anti-TRK1 antibody produced in rabbit, Anti-neurotrophic tyrosine kinase, receptor, type 1 antibody produced in rabbit

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About This Item

MDL number:
MFCD00239748
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~140 kDa

species reactivity

mouse, human, rat

concentration

1 mg/mL

technique(s)

indirect immunofluorescence: 1:100-1:200

isotype

IgG

immunogen sequence

(P-V-YP-L-D)

NCBI accession no.

NP_001007793.1

UniProt accession no.

P04629

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer791)

Gene Information

human ... NTRK1(4914)

Related Categories

Immunogen

Peptide sequence around phosphorylation site of tyrosine791 (P-V-Y(p)-L-D), according to the protein NTRK1.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
951411326

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Kenji Kita et al.
Cancer medicine, 6(12), 2972-2983 (2017-11-11)
Molecular-targeted drugs are generally effective against tumors containing driver oncogenes, such as EGFR, ALK, and NTRK1. However, patients harboring these oncogenes frequently experience a progression of brain metastases during treatment. Here, we present an in vivo imaging model for brain
Ming-Ming Chen et al.
The Journal of nutritional biochemistry, 46, 57-67 (2017-05-02)
Injuries and diseases that occur in the nervous system are common and have few effective treatments. Previous studies have shown that quercetin has a therapeutic effect on nervous system injuries, but its potential effects on and mechanisms of action related
Hua Fang et al.
Experimental and therapeutic medicine, 14(1), 652-656 (2017-07-05)
Neurotrophic factor (NF) and Trk signaling mechanisms underlying the promotion of motor recovery following acute spinal cord injury (SCI) in rats were investigated. Thirty-six adult Sprague-Dawley rats of both genders were randomly divided into three groups: Sham-operated, model, and NF/Trk.
Junya Onodera et al.
Glia, 69(4), 890-904 (2020-10-30)
Brain-derived neurotrophic factor (BDNF), a main member of the neurotrophin family that is active in the brain, supports neuronal survival and growth. Microglial BDNF affects both the structural and functional properties of neurons. In contrast, whether and how neuronal BDNF
Shingo Suzuki et al.
Peptides, 89, 42-49 (2017-01-26)
Accumulating evidence suggests functional interaction between brain-derived neurotrophic factor (BDNF) and metabotropic glutamate receptor (mGluR) signaling pathways in the central nervous system (CNS). To date, eight subtypes of mGluRs, mGluR1-8, have been identified, and a previous study suggested that BDNF
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