SAB4200394
Anti-Nestin (C-terminal) antibody produced in rabbit
~1.5 mg/mL, affinity isolated antibody
Synonym(s):
Anti-NES
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~300 kDa
species reactivity
mouse, rat
packaging
antibody small pack of 25 μL
General description
Nestin/NES belongs to the intermediate filament (IF) protein family. Its expression is found in immature neuroepithelial and progenitor cell types. This 240 kDa protein contains the shortest head domain (N-terminus) and a long tail domain (C-terminus). Nestin is mapped to human chromosome 1q23.1.
Immunogen
synthetic peptide corresponding to a sequence at the C- terminus of mouse nestin, conjugated to KLH. The sequence is identical in rat nestin.
Application
Anti-Nestin (C-terminal) antibody has been used in immunostaining.
Biochem/physiol Actions
Nestin/NES plays a major role in the modulation of assembly and disassembly of intermediate filaments, which in turn help in the remodeling of the cell along with other structural proteins.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Nestin-expressing cell types in the temporal lobe and hippocampus: Morphology, differentiation, and proliferative capacity.
Liu J, et al.
Glia, 66(1), 62-77 (2018)
Nestin structure and predicted function in cellular cytoskeletal organisation.
Michalczyk K and Ziman M
Histology and Histopathology, 20(2), 665-671 (2005)
YAP stabilizes SMAD1 and promotes BMP2-induced neocortical astrocytic differentiation.
Huang Z, et al.
Development, 143(13), 2398-2409 (2016)
Nestin expression in embryonic human neuroepithelium and in human neuroepithelial tumor cells.
Tohyama T, et al.
Laboratory Investigation; a Journal of Technical Methods and Pathology, 66(3), 303-313 (1992)
Intermediate filaments in peripheral nervous system: Their expression, dysfunction and diseases
Parlakian A, et al.
Revista de Neurologia, 172(10), 607-613 (2016)
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