SAB1309054

[KO Validated]Anti-Presenilin 1 antibody produced in rabbit

[Knockout Validated],purified polyclonal antibody, buffered aqueous solution

• Synonym(s): Presenilin-1, PS-1, 3423-, Protein S182, Presenilin-1 NTF subunit, Presenilin-1 CTF subunit, Presenilin-1 CTF12, PS1-CTF12, PSEN1, AD3, PS1, PSNL1
• UNSPSC Code: 12352203

Properties

• biological source: (Human)
• conjugate: unconjugated
• antibody form: purified antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: liquid
• mol wt: 280739Da
• species reactivity: mouse, human
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50~100; western blot: 1:1000; western blot: 1:500-1:2000
• isotype: IgG
• NCBI accession no.: P49769; Q8HXW5; P97887
• storage temp.: -10 to -25°C
• target post-translational modification: unmodified
• Gene Information: human ... PSEN1(5663)

Description

General description

Alzheimer′s disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes.

Specificity

This Presenilin 1 (PSEN1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 330-359 amino acids from the C-terminal region of human Presenilin 1 (PSEN1).

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable